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  Multi-echo investigations of positive and negative CBF and concomitant BOLD changes: Positive and negative CBF and BOLD changes

Devi, R., Lepsien, J., Lorenz, K., Schlumm, T., Mildner, T., & Möller, H. E. (2022). Multi-echo investigations of positive and negative CBF and concomitant BOLD changes: Positive and negative CBF and BOLD changes. NeuroImage, 263: 119661. doi:10.1016/j.neuroimage.2022.119661.

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 Creators:
Devi, Ratnamanjuri1, Author                 
Lepsien, Jöran1, Author           
Lorenz, Kathrin1, Author           
Schlumm, Torsten1, Author           
Mildner, Toralf1, Author           
Möller, Harald E.1, Author           
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              

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Free keywords: Flow-metabolism coupling; Functional changes; Functional CBF changes; Multi-echo center-out EPI; Negative BOLD response; Simultaneous BOLD and CBF measurements
 Abstract: Unlike the positive blood oxygenation level-dependent (BOLD) response (PBR), commonly taken as an indication of an ‘activated’ brain region, the physiological origin of negative BOLD signal changes (i.e. a negative BOLD response, NBR), also referred to as ‘deactivation’ is still being debated. In this work, an attempt was made to gain a better understanding of the underlying mechanism by obtaining a comprehensive measure of the contributing cerebral blood flow (CBF) and its relationship to the NBR in the human visual cortex, in comparison to a simultaneously induced PBR in surrounding visual regions. To overcome the low signal-to-noise ratio (SNR) of CBF measurements, a newly developed multi-echo version of a center-out echo planar-imaging (EPI) readout was employed with pseudo-continuous arterial spin labeling (pCASL). It achieved very short echo and inter-echo times and facilitated a simultaneous detection of functional CBF and BOLD changes at 3 T with improved sensitivity. Evaluations of the absolute and relative changes of CBF and the effective transverse relaxation rate, , the coupling ratios, and their dependence on CBF at rest, , indicated differences between activated and deactivated regions. Analysis of the shape of the respective functional responses also revealed faster negative responses with more pronounced post-stimulus transients. Resulting differences in the flow-metabolism coupling ratios were further examined for potential distinctions in the underlying neuronal contributions.

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Language(s): eng - English
 Dates: 2022-09-272022-08-262022-09-302022-10-022022-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuroimage.2022.119661
Other: online ahead of print
PMID: 36198353
 Degree: -

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 263 Sequence Number: 119661 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166