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  High-resolution magnetization-transfer imaging of post-mortem marmoset brain: Comparisons with relaxometry and histology

Marschner, H., Pampel, A., Müller, R., Reimann, K., Bock, N., Morawski, M., et al. (2023). High-resolution magnetization-transfer imaging of post-mortem marmoset brain: Comparisons with relaxometry and histology. NeuroImage, 268: 119860. doi:10.1016/j.neuroimage.2023.119860.

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 Urheber:
Marschner, Henrik1, Autor                 
Pampel, André1, Autor           
Müller, Roland1, Autor                 
Reimann, Katja2, Autor
Bock, Nicolas3, Autor
Morawski, Markus2, Autor                 
Geyer, Stefan4, Autor           
Möller, Harald E.1, Autor           
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Paul Flechsig Institute for Brain Research, University of Leipzig, Germany, ou_persistent22              
3Department of Psychology, Neuroscience, and Behaviour, McMaster University, Hamilton, ON, Canada, ou_persistent22              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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Schlagwörter: Transverse relaxation; Histology; Iron; Longitudinal relaxation; Macromolecular pool; Magnetization transfer; Myelin
 Zusammenfassung: Cell membranes and macromolecules or paramagnetic compounds interact with water proton spins, which modulates magnetic resonance imaging (MRI) contrast providing information on tissue composition. For a further investigation, quantitative magnetization transfer (qMT) parameters (at 3T), including the ratio of the macromolecular and water proton pools, F, and the exchange-rate constant as well as the (observed) longitudinal and the effective transverse relaxation rates (at 3T and 7T), R1obs and R2*, respectively, were measured at high spatial resolution (200 µm) in a slice of fixed marmoset brain and compared to histology results obtained with Gallyas' myelin stain and Perls' iron stain. R1obs and R2* were linearly correlated with the iron content for the entire slice, whereas distinct differences were obtained between gray and white matter for correlations of relaxometry and qMT parameters with myelin content. The combined results suggest that the macromolecular pool interacting with water consists of myelin and (less efficient) non-myelin contributions. Despite strong correlation of F and R1obs, none of these parameters was uniquely specific to myelination. Due to additional sensitivity to iron stores, R1obs and R2* were more sensitive for depicting microstructural differences between cortical layers than F.

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Sprache(n): eng - English
 Datum: 2022-12-282022-08-302023-01-032023-01-052023-03
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1016/j.neuroimage.2023.119860
Anderer: epub 2023
PMID: 36610679
 Art des Abschluß: -

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Projektname : Helmholtz Alliance “ICEMED—Imaging and Curing Environmental Metabolic Diseases”
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Förderorganisation : Helmholtz Association
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Förderorganisation : Max Planck Society

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Titel: NeuroImage
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Orlando, FL : Academic Press
Seiten: - Band / Heft: 268 Artikelnummer: 119860 Start- / Endseite: - Identifikator: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166