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  Time domains of hypoxia responses and -omics insights

Yu, J. J., Non, A. L., Heinrich, E. C., Gu, W., Alcock, J., Moya, E. A., et al. (2022). Time domains of hypoxia responses and -omics insights. Frontiers in Physiology, 13: 885295. doi:10.3389/fphys.2022.885295.

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Yu_Time_FrontPhys_2022.pdf (Publisher version), 4MB
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 Creators:
Yu, James J., Author
Non, Amy L., Author
Heinrich, Erica C., Author
Gu, Wanjun, Author
Alcock, Joe, Author
Moya, Esteban A., Author
Lawrence, Elijah S., Author
Tift, Michael S., Author
O'Brien, Katie A., Author
Storz, Jay F., Author
Signore, Anthony V., Author
Khudyakov, Jane I., Author
Milsom, William K., Author
Wilson, Sean M., Author
Beall, Cynthia M., Author
Villafuerte, Francisco C., Author
Stobdan, Tsering, Author
Julian, Colleen G., Author
Moore, Lorna G., Author
Fuster, Mark M., Author
Stokes, Jennifer A., AuthorMilner, Richard, AuthorWest, John B., AuthorZhang, Jiao, AuthorShyy, John Y., AuthorChildebayeva, Ainash1, Author                 Vázquez-Medina, José Pablo, AuthorPham, Luu V., AuthorMesarwi, Omar A., AuthorHall, James E., AuthorCheviron, Zachary A., AuthorSieker, Jeremy, AuthorBlood, Arlin B., AuthorYuan, Jason X., AuthorScott, Graham R., AuthorRana, Brinda K., AuthorPonganis, Paul J., AuthorMalhotra, Atul, AuthorPowell, Frank L., AuthorSimonson, Tatum S., Author more..
Affiliations:
1Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, ou_3222712              

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Free keywords: hypoxia, adaptation, high altitude, oxygen, integrative physiology
 Abstract: The ability to respond rapidly to changes in oxygen tension is critical for many forms of life. Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and biomedicine, provide important insights into mechanisms of hypoxia adaptation and tolerance. Here we synthesize findings across varying time domains of hypoxia in terms of oxygen delivery, ranging from early animal to modern human evolution and examine the potential impacts of environmental and clinical challenges through emerging multi-omics approaches. We discuss how diverse animal species have adapted to hypoxic environments, how humans vary in their responses to hypoxia (i.e., in the context of high-altitude exposure, cardiopulmonary disease, and sleep apnea), and how findings from each of these fields inform the other and lead to promising new directions in basic and clinical hypoxia research.

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Language(s): eng - English
 Dates: 2022-08-08
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3389/fphys.2022.885295
 Degree: -

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Title: Frontiers in Physiology
Source Genre: Journal
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Pages: - Volume / Issue: 13 Sequence Number: 885295 Start / End Page: - Identifier: ISSN: 1664-042X