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  Different brain areas require different analysis models: fMRI observations in Parkinson’s disease

Torrecuso, R., Mueller, K., Holiga, Š., Urgosik, D., Vymazal, J., Sieger, T., et al. (2022). Different brain areas require different analysis models: fMRI observations in Parkinson’s disease. In Proceedings of the ISMRM 31st Annual Meeting & Exhibition.

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ViewSubmission (1).pdf (Publisher version), 597KB
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ISMRM 2022 submited abstract
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 Creators:
Torrecuso, Renzo1, Author           
Mueller, Karsten1, 2, Author           
Holiga, Štefan1, 3, Author           
Urgosik, Dusan4, Author
Vymazal, Josef5, Author
Sieger, Tomas6, Author
Růžička, Filip7, Author
Růžička, Evzen8, Author
Schroeter, Matthias L.9, 10, Author           
Jech, Robert4, Author
Möller, Harald E.1, Author           
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Method and Development Group Neural Data Science and Statistical Computing, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_3282987              
3Roche Pharma Research and Early Development, Roche Innovation Center, Basel, Switzerland, ou_persistent22              
4Department of Neurology, Charles University in Prague | CUNI , Prague, Czech Republic, ou_persistent22              
5CULS · Faculty of Environmental Science, Czech University of Life Sciences Prague, Prague, Czech Republic, ou_persistent22              
6Department of Neurology and Center of Clinical Neuroscience, Charles University in Prague, Prague, Czech Republic, ou_persistent22              
7Department of Environmental Engineering, Faculty of TechnologyTomas Bata University in Zlín, Zlin, Czech Republic, ou_persistent22              
8Neurology, General University Hospital in Prague, Prague, Czech Republic, ou_persistent22              
9Clinic for Cognitive Neurology, University Hospital Leipzig, Leipzig, Germany, ou_persistent22              
10Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: basal ganglia; experimental design; fMRI; motor circuit; Parkinson's disease; treatment effect
 Abstract: Foreseeing how specific brain areas respond in time to a stimulus can be a prerequisite for a successfully conceived fMRI experiment. We demonstrate that in medicated Parkinson’s disease patients, putamen's activation peaks around the onset of tapping but does not persist throughout the tapping block, whereas sustained activation is observed in the motor cortex. Consequently, in the widely used tapping paradigm “On vs. Off L-DOPA”, the drug effect remains undetected if statistical analysis apply a block design instead of an event-related one. Ignoring this information can lead to fallacious conclusions which suggests using different models to investigate different brain regions.

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 Dates: 20222022
 Publication Status: Published in print
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Title: 2022 ISMRM Conference & Exhibition
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Start-/End Date: 2022-05-07 - 2022-05-12
Invited: Yes

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Title: Proceedings of the ISMRM 31st Annual Meeting & Exhibition
Source Genre: Proceedings
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