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  Collagen pre-strain discontinuity at the bone—cartilage interface

Badar, W., Ali, H., Brooker, O. N., Newham, E., Snow, T., Terrill, N. J., et al. (2022). Collagen pre-strain discontinuity at the bone—cartilage interface. PLoS One, 17(9): e0273832. doi:10.1371/journal.pone.0273832.

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 Creators:
Badar, Waqas, Author
Ali, Husna, Author
Brooker, Olivia N., Author
Newham, Elis, Author
Snow, Tim, Author
Terrill, Nicholas J., Author
Tozzi, Gianluca, Author
Fratzl, Peter1, Author           
Knight, Martin M., Author
Gupta, Himadri S., Author
Affiliations:
1Peter Fratzl, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863294              

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 Abstract: The bone-cartilage unit (BCU) is a universal feature in diarthrodial joints, which is mechanically-graded and subjected to shear and compressive strains. Changes in the BCU have been linked to osteoarthritis (OA) progression. Here we report existence of a physiological internal strain gradient (pre-strain) across the BCU at the ultrastructural scale of the extracellular matrix (ECM) constituents, specifically the collagen fibril. We use X-ray scattering that probes changes in the axial periodicity of fibril-level D-stagger of tropocollagen molecules in the matrix fibrils, as a measure of microscopic pre-strain. We find that mineralized collagen nanofibrils in the calcified plate are in tensile pre-strain relative to the underlying trabecular bone. This behaviour contrasts with the previously accepted notion that fibrillar pre-strain (or D-stagger) in collagenous tissues always reduces with mineralization, via reduced hydration and associated swelling pressure. Within the calcified part of the BCU, a finer-scale gradient in pre-strain (0.6% increase over ~50μm) is observed. The increased fibrillar pre-strain is linked to prior research reporting large tissue-level residual strains under compression. The findings may have biomechanical adaptative significance: higher in-built molecular level resilience/damage resistance to physiological compression, and disruption of the molecular-level pre-strains during remodelling of the bone-cartilage interface may be potential factors in osteoarthritis-based degeneration.

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Language(s): eng - English
 Dates: 2022-09-152022
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1371/journal.pone.0273832
PMID: 0633
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Title: PLoS One
  Abbreviation : PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 17 (9) Sequence Number: e0273832 Start / End Page: - Identifier: ISSN: 1932-6203