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  Co-translational assembly orchestrates competing biogenesis pathways

Seidel, M., Becker, A., Pereira, F., Landry, J. J. M., de Azevedo, N. T. D., Fusco, C. M., Kaindl, E., Romanov, N., Baumbach, J., Langer, J. D., Schuman, E. M., Patil, K. R., Hummer, G., Benes, V., & Beck, M. (2022). Co-translational assembly orchestrates competing biogenesis pathways. Nat. Commun., 13(1224). doi:10.1038/s41467-022-28878-5.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-000B-21B8-0 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000B-21B9-F
資料種別: 学術論文

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s41467-022-28878-5-1.pdf (出版社版), 3MB
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ファイルのパーマリンク:
https://hdl.handle.net/21.11116/0000-000B-21BA-E
ファイル名:
s41467-022-28878-5-1.pdf
説明:
-
OA-Status:
Gold
閲覧制限:
公開
MIMEタイプ / チェックサム:
application/pdf / [MD5]
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著作権日付:
2022
著作権情報:
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
CCライセンス:
ttp://creativecommons.org/ licenses/by/4.0/

関連URL

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URL:
https://pubmed.ncbi.nlm.nih.gov/35264577/ (全文テキスト（全般）)
説明:
-
OA-Status:
Gold

作成者

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 作成者:
Seidel, Maximilian1, 2, 著者
Becker, Anja1, 著者
Pereira, Filipa3, 4, 著者
Landry, Jonathan J M5, 著者
de Azevedo, Nayara Trevisan Doimo5, 著者
Fusco, Claudia M6, 著者
Kaindl, Eva1, 著者
Romanov, Natalie1, 著者
Baumbach, Janina1, 3, 著者
Langer, Julian D6, 7, 8, 著者
Schuman, Erin M.6, 著者           
Patil, Kiran Raosaheb3, 9, 著者
Hummer, Gerhard10, 11, 著者
Benes, Vladimir5, 著者
Beck, Martin1, 3, 著者
所属:
1Department of Molecular Sociology, Max Planck Institute of Biophysics, Frankfurt, Germany, ou_persistent22              
2Faculty of Bioscience, Heidelberg University, Heidelberg, Germany., ou_persistent22              
3Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany., ou_persistent22              
4Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA., ou_persistent22              
5Genomics Core Facility, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany., ou_persistent22              
6Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society, ou_2461710              
7Membrane Proteomics and Mass Spectrometry, Max Planck Institute of Biophysics, Frankfurt, Germany, ou_persistent22              
8Mass Spectrometry, Max Planck Institute for Brain Research, Frankfurt, Germany., ou_persistent22              
9 Medical Research Council Toxicology Unit, University of Cambridge, Cambridge, United Kingdom, ou_persistent22              
10Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt, Germany., ou_persistent22              
11Institute of Biophysics, Goethe University Frankfurt, Frankfurt, Germany., ou_persistent22              

内容説明

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キーワード: Nuclear pore complex RNA RNA sequencing Translation
 要旨: During the co-translational assembly of protein complexes, a fully synthesized subunit engages with the nascent chain of a newly synthesized interaction partner. Such events are thought to contribute to productive assembly, but their exact physiological relevance remains underexplored. Here, we examine structural motifs contained in nucleoporins for their potential to facilitate co-translational assembly. We experimentally test candidate structural motifs and identify several previously unknown co-translational interactions. We demonstrate by selective ribosome profiling that domain invasion motifs of beta-propellers, coiled-coils, and short linear motifs may act as co-translational assembly domains. Such motifs are often contained in proteins that are members of multiple complexes (moonlighters) and engage with closely related paralogs. Surprisingly, moonlighters and paralogs assemble co-translationally in only some but not all of the relevant biogenesis pathways. Our results highlight the regulatory complexity of assembly pathways.

資料詳細

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言語: eng - English
 日付: 2021-07-272022-02-112022-03-09
 出版の状態: オンラインで出版済み
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: DOI: 10.1038/s41467-022-28878-5
PMID: 35264577
 学位: -

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Project information

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Project name : Specialized Ribosomes for Neuronal Protein Synthesis (NeuroRibo)
Grant ID : 743216
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)

出版物 1

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出版物名: Nat. Commun.
  省略形 : Nat. Commun.
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: London : Nature Publishing Group
ページ: - 巻号: 13 (1224) 通巻号: - 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723