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  Zwitterionic dendrimersomes : a closer xenobiotic mimic of cell membranes

Joseph, A., Wagner, A. M., Garay-Sarmiento, M., Aleksanyan, M., Haraszti, T., Söder, D., et al. (2022). Zwitterionic dendrimersomes: a closer xenobiotic mimic of cell membranes. Advanced Materials, 2206288. doi:10.1002/adma.202206288.

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 Creators:
Joseph, Anton, Author
Wagner, Anna M., Author
Garay-Sarmiento, Manuela, Author
Aleksanyan, Mina1, Author                 
Haraszti, Tamás, Author
Söder, Dominik, Author
Georgiev, Vasil N.1, Author
Dimova, Rumiana2, Author                 
Percec, Virgil, Author
Rodriguez-Emmenegger, Cesar, Author
Affiliations:
1Rumiana Dimova, Kolloidchemie, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_3360040              
2Rumiana Dimova, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863328              

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Free keywords: biosensor; bottom-up synthetic biology; hybrid vesicles; synthetic cells; vesicle fusion; vesicle motility; zwitterionic dendrimersomes
 Abstract: Building functional mimics of cell membranes is an important task toward the development of synthetic cells. So far, lipid and amphiphilic block copolymers are the most widely used amphiphiles with the bilayers by the former lacking stability while membranes by the latter are typically characterized by very slow dynamics. Herein, we introduce a new type of Janus dendrimer containing a zwitterionic phosphocholine hydrophilic headgroup (JDPC) and a 3,5-substituted dihydrobenzoate-based hydrophobic dendron. JDPC self-assembles in water into zwitterionic dendrimersomes (z-DSs) that faithfully recapitulate the cell membrane in thickness, flexibility, and fluidity, while being resilient to harsh conditions and displaying faster pore closing dynamics in the event of membrane rupture. This enables the fabrication of hybrid DSs with components of natural membranes, including pore-forming peptides, structure-directing lipids, and glycans to create raft-like domains or onion vesicles. Moreover, z-DSs can be used to create active synthetic cells with life-like features that mimic vesicle fusion and motility as well as environmental sensing. Despite their fully synthetic nature, z-DSs are minimal cell mimics that can integrate and interact with living matter with the programmability to imitate life-like features and beyond. This article is protected by copyright.

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Language(s): eng - English
 Dates: 2022-09-22
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/adma.202206288
 Degree: -

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Title: Advanced Materials
  Other : Adv. Mater.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: - Sequence Number: 2206288 Start / End Page: - Identifier: ISSN: 0935-9648