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  Suppressors of fixation can increase average fitness beyond amplifiers of selection

Sharma, N., & Traulsen, A. (2022). Suppressors of fixation can increase average fitness beyond amplifiers of selection. Proceedings of the National Academy of Sciences of the United States of America, 119(37): e2205424119. doi:10.1073/pnas.2205424119.

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 Urheber:
Sharma, Nikhil1, 2, Autor           
Traulsen, Arne2, Autor           
Affiliations:
1IMPRS for Evolutionary Biology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445639              
2Department Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445641              

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Schlagwörter: evolutionary graph theory; mutation-selection balance; low mutation rates; deleterious mutant regime
 Zusammenfassung: Evolutionary dynamics on graphs has remarkable features: For example, it has been shown that amplifiers of selection exist that—compared to an unstructured population—increase the fixation probability of advantageous mutations, while they decrease the fixation probability of disadvantageous mutations. So far, the theoretical literature has focused on the case of a single mutant entering a graph-structured population, asking how the graph affects the probability that a mutant takes over a population and the time until this typically happens. For continuously evolving systems, the more relevant case is that mutants constantly arise in an evolving population. Typically, such mutations occur with a small probability during reproduction events. We thus focus on the low mutation rate limit. The probability distribution for the fitness in this process converges to a steady state at long times. Intuitively, amplifiers of selection are expected to increase the population’s mean fitness in the steady state. Similarly, suppressors of selection are expected to decrease the population’s mean fitness in the steady state. However, we show that another set of graphs, called suppressors of fixation, can attain the highest population mean fitness. The key reason behind this is their ability to efficiently reject deleterious mutants. This illustrates the importance of the deleterious mutant regime for the long-term evolutionary dynamics, something that seems to have been overlooked in the literature so far.

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Sprache(n): eng - English
 Datum: 2022-03-282022-08-032022-09-062022-09-13
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
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 Identifikatoren: DOI: 10.1073/pnas.2205424119
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Titel: Proceedings of the National Academy of Sciences of the United States of America
  Andere : PNAS
  Andere : Proceedings of the National Academy of Sciences of the USA
  Kurztitel : Proc. Natl. Acad. Sci. U. S. A.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Washington, D.C. : National Academy of Sciences
Seiten: - Band / Heft: 119 (37) Artikelnummer: e2205424119 Start- / Endseite: - Identifikator: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230