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  The attention-emotion interaction in healthy female participants on oral contraceptives during 1-week escitalopram intake

Beinhölzl, N., Molloy, E., Zsido, R., Richter, T., Piecha, F. A., Zheleva, G., et al. (2022). The attention-emotion interaction in healthy female participants on oral contraceptives during 1-week escitalopram intake. Frontiers in Neuroscience, 16: 809269. doi:10.3389/fnins.2022.809269.

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 Creators:
Beinhölzl, Nathalie1, 2, Author                 
Molloy, Eoin2, 3, 4, Author                 
Zsido, Rachel1, 2, 5, Author                 
Richter, Thalia6, 7, Author
Piecha, Fabian A.1, 2, Author
Zheleva, Gergana1, 2, Author
Scharrer, Ulrike1, 2, Author
Regenthal, Ralf8, Author
Villringer, Arno2, 5, 9, 10, Author                 
Okon-Singer, Hadas6, 7, Author
Sacher, Julia2, 5, 9, 11, Author                 
Affiliations:
1Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3230775              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3University Clinic for Radiology and Nuclear Medicine, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
4German Center for Neurodegenerative Diseases, Magdeburg, Germany, ou_persistent22              
5Max Planck School of Cognition, Leipzig, Germany, ou_persistent22              
6Department of Psychology, University of Haifa, Israel, ou_persistent22              
7Integrated Brain and Behavior Research Center (IBBR), University of Haifa, Israel, ou_persistent22              
8Division of Clinical Pharmacology, Rudolf-Boehm-Institute of Pharmacology and Toxicology, University of Leipzig, Germany, ou_persistent22              
9Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
10MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
11Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Helios Park Hospital Leipzig, Germany, ou_persistent22              

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Free keywords: Attention-emotion interaction; Emotional flanker task; Female mental health; Oral hormonal contraceptives; Selective serotonin reuptake inhibitors
 Abstract: Previous findings in healthy humans suggest that selective serotonin reuptake inhibitors (SSRIs) modulate emotional processing via earlier changes in attention. However, many previous studies have provided inconsistent findings. One possible reason for such inconsistencies is that these studies did not control for the influence of either sex or sex hormone fluctuations. To address this inconsistency, we administered 20 mg escitalopram or placebo for seven consecutive days in a randomized, double-blind, placebo-controlled design to sixty healthy female participants with a minimum of 3 months oral contraceptive (OC) intake. Participants performed a modified version of an emotional flanker task before drug administration, after a single dose, after 1 week of SSRI intake, and after a 1-month wash-out period. Supported by Bayesian analyses, our results do not suggest a modulatory effect of escitalopram on behavioral measures of early attentional-emotional interaction in female individuals with regular OC use. While the specific conditions of our task may be a contributing factor, it is also possible that a practice effect in a healthy sample may mask the effects of escitalopram on the attentional-emotional interplay. Consequently, 1 week of escitalopram administration may not modulate attention toward negative emotional distractors outside the focus of attention in healthy female participants taking OCs. While further research in naturally cycling females and patient samples is needed, our results represent a valuable contribution toward the preclinical investigation of antidepressant treatment.

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Language(s): eng - English
 Dates: 2021-11-042022-08-082022-09-09
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3389/fnins.2022.809269
Other: eCollection 2022
PMID: 36161146
PMC: PMC9500523
 Degree: -

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Project name : -
Grant ID : 25032
Funding program : -
Funding organization : National Association for Research on Schizophrenia and Depression (NARSAD)

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Title: Frontiers in Neuroscience
  Other : Front Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 16 Sequence Number: 809269 Start / End Page: - Identifier: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-4548