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  Schwann cell precursors represent a neural crest‐like state with biased multipotency

Kastriti, M. E., Faure, L., Von Ahsen, D., Bouderlique, T. G., Boström, J., Solovieva, T., et al. (2022). Schwann cell precursors represent a neural crest‐like state with biased multipotency. The EMBO Journal, 41(17): e108780. doi:10.15252/embj.2021108780.

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The EMBO Journal - 2022 - Kastriti - Schwann cell precursors represent a neural crest%u2010like state with biased multipotency.pdf (Verlagsversion), 9MB
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Kastriti, Maria Eleni, Autor
Faure, Louis, Autor
Von Ahsen, Dorothea, Autor
Bouderlique, Thibault Gerald, Autor
Boström, Johan, Autor
Solovieva, Tatiana, Autor
Jackson, Cameron, Autor
Bronner, Marianne, Autor
Meijer, Dies, Autor
Hadjab, Saida, Autor
Lallemend, Francois, Autor
Erickson, Alek, Autor
Kaucka, Marketa1, Autor           
Dyachuk, Viacheslav, Autor
Perlmann, Thomas, Autor
Lahti, Laura, Autor
Krivanek, Jan, Autor
Brunet, Jean‐Francois, Autor
Fried, Kaj, Autor
Adameyko, Igor, Autor
Affiliations:
1Max Planck Research Group Craniofacial Biology (Kaucka Petersen), Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_3164874              

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Schlagwörter: multipotency; neural crest; regulons; Schwann cell precursors; Schwann cell lineage
 Zusammenfassung: Schwann cell precursors (SCPs) are nerve-associated progenitors that can generate myelinating and non-myelinating Schwann cells but also are multipotent like the neural crest cells from which they originate. SCPs are omnipresent along outgrowing peripheral nerves throughout the body of vertebrate embryos. By using single-cell transcriptomics to generate a gene expression atlas of the entire neural crest lineage, we show that early SCPs and late migratory crest cells have similar transcriptional profiles characterised by a multipotent “hub” state containing cells biased towards traditional neural crest fates. SCPs keep diverging from the neural crest after being primed towards terminal Schwann cells and other fates, with different subtypes residing in distinct anatomical locations. Functional experiments using CRISPR-Cas9 loss-of-function further show that knockout of the common “hub” gene Sox8 causes defects in neural crest-derived cells along peripheral nerves by facilitating differentiation of SCPs towards sympathoadrenal fates. Finally, specific tumour populations found in melanoma, neurofibroma and neuroblastoma map to different stages of SCP/Schwann cell development. Overall, SCPs resemble migrating neural crest cells that maintain multipotency and become transcriptionally primed towards distinct lineages.

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Sprache(n): eng - English
 Datum: 2021-05-202022-06-152022-07-112022-09-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.15252/embj.2021108780
 Art des Abschluß: -

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Titel: The EMBO Journal
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Nature Publishing Group
Seiten: - Band / Heft: 41 (17) Artikelnummer: e108780 Start- / Endseite: - Identifikator: ISSN: 0261-4189
CoNE: https://pure.mpg.de/cone/journals/resource/954925497061_1