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Free keywords:
carbonyl reduction; carboxylic acid; heterogeneous catalysis; hydrogenation; metal catalysis
Abstract:
This critical review discusses the synthesis of alcohols via hydrogenation of carboxylic acids promoted by heterogeneous metal catalysis. The introductory chapter rationalizes the comparative reactivity of carboxylic acid derivatives, which is proceeded by a description of different mechanisms for carboxylic acid hydrogenation. We then discuss reaction pathways that give rise to undesired side products, before comparing the reactivity of different classes of carboxylic acid substrates with a focus on biomass-derived carboxylic acids. The final portion of the review aims to guide researchers in the selection of appropriate reaction conditions, such as the choice of solvent, transition metal, and catalyst support.
