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  Heritability of hippocampal functional and microstructural organisation

Bayrak, S., de Wael, R. V., Schaare, H. L., Hettwer, M., Caldairou, B., Bernasconi, A., et al. (2022). Heritability of hippocampal functional and microstructural organisation. NeuroImage, 264: 119656. doi:10.1016/j.neuroimage.2022.119656.

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 Creators:
Bayrak, Seyma1, 2, 3, Author                 
de Wael, Reinder Vos4, Author
Schaare, Herma Lina1, 2, Author                 
Hettwer, Meike1, 2, 5, 6, Author           
Caldairou, Benoit7, Author
Bernasconi, Andrea7, Author
Bernasconi, Neda7, Author
Bernhardt, Boris C.4, Author
Valk, Sofie L.1, 2, Author                 
Affiliations:
1Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              
2Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, QC, Canada, ou_persistent22              
5Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany, ou_persistent22              
6Max Planck School of Cognition, Max Planck Institute of Human Cognitive and Brain Sciences, Leipzig, Germany, ou_persistent22              
7Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute and Hospital, McGill University, QC, Canada, ou_persistent22              

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Free keywords: Hippocampus; Hippocampal subfields; Gradients; Heritability; Microstructure functional connectivity
 Abstract: The hippocampus is a uniquely infolded allocortical structure in the medial temporal lobe that consists of the microstructurally and functionally distinct subregions: subiculum, cornu ammonis, and dentate gyrus. The hippocampus is a remarkably plastic region that is implicated in learning and memory. At the same time it has been shown that hippocampal subregion volumes are heritable, and that genetic expression varies along a posterior to anterior axis. Here, we studied how a heritable, stable, hippocampal organisation may support its flexible function in healthy adults. Leveraging the twin set-up of the Human Connectome Project with multimodal neuroimaging, we observed that the functional connectivity between hippocampus and cortex was heritable and that microstructure of the hippocampus genetically correlated with cortical microstructure. Moreover, both functional and microstructural organisation could be consistently captured by anterior-to-posterior and medial-to-lateral axes across individuals. However, heritability of functional, relative to microstructural, organisation was found reduced, suggesting individual variation in functional organisation may be explained by experience-driven factors. Last, we demonstrate that structure and function couple along an inherited macroscale organisation, suggesting an interplay of stability and plasticity within the hippocampus. Our study provides new insights on the heritability of the hippocampal of the structure and function within the hippocampal organisation.

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Language(s): eng - English
 Dates: 2022-09-182022-09-282022-09-302022-12-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuroimage.2022.119656
Other: online ahead of print
PMID: 36183945
 Degree: -

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Project name : -
Grant ID : 785907
Funding program : Horizon 2020
Funding organization : European Union

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 264 Sequence Number: 119656 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166