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  Xenopus paraxial protocadherin has signaling functions and is involved in tissue separation

Medina, A., Swain, R., Kuerner, K.-M., & Steinbeisser, H. (2004). Xenopus paraxial protocadherin has signaling functions and is involved in tissue separation. EMBO Journal, 23(16), 3249-3258. doi:10.1038/sj.emboj.7600329.

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Medina, A1, Author           
Swain, RK1, Author                 
Kuerner, K-M1, Author           
Steinbeisser, H1, Author           
Affiliations:
1Department Cell Biology, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3375717              

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 Abstract: Protocadherins have homophilic adhesion properties and mediate selective cell-cell adhesion and cell sorting. Knockdown of paraxial protocadherin (PAPC) function in the Xenopus embryo impairs tissue separation, a process that regulates separation of cells of ectodermal and mesodermal origin during gastrulation. We show that PAPC can modulate the activity of the Rho GTPase and c-jun N-terminal kinase, two regulators of the cytoskeletal architecture and effectors of the planar cell polarity pathway. This novel signaling function of PAPC is essential for the regulation of tissue separation. In addition, PAPC can interact with the Xenopus Frizzled 7 receptor, and both proteins contribute to the development of separation behavior by activating Rho and protein kinase Calpha.

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 Dates: 2004-08
 Publication Status: Issued
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 Rev. Type: -
 Identifiers: DOI: 10.1038/sj.emboj.7600329
PMID: 15272309
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Title: EMBO Journal
  Other : EMBO J.
Source Genre: Journal
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Publ. Info: Nature Publishing Group
Pages: - Volume / Issue: 23 (16) Sequence Number: - Start / End Page: 3249 - 3258 Identifier: ISSN: 0261-4189
CoNE: https://pure.mpg.de/cone/journals/resource/954925497061