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  Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice

Korte, M., Griesbeck, O., Gravel, C., Carroll, P., Staiger, V., Thoenen, H., et al. (1996). Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice. Proceedings of the National Academy of Sciences of the United States of America, 93(22), 12547-12552. doi:10.1073/pnas.93.22.12547.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000B-3A46-6 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000B-3A47-5
Genre: Zeitschriftenartikel

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 Urheber:
Korte, M.1, Autor           
Griesbeck, O.1, Autor           
Gravel, C., Autor
Carroll, P.1, Autor           
Staiger, V.1, Autor           
Thoenen, H.1, Autor           
Bonhoeffer, Tobias1, Autor           
Affiliations:
1Theoretisches Teilinstitut Psychiatrie, MPI of Neurobiology, Max Planck Society, Am Klopferspitz 18, 82152 Martinsried, DE, ou_3359995              

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Schlagwörter: neurotrophins adenovirus rat visual-cortex growth-factor ngf synaptic transmission nervous-system monocular deprivation adenovirus vectors messenger-rna neurons bdnf nt-3 Science & Technology - Other Topics
 Zusammenfassung: Long-term potentiation (LTP) has been shown to be impaired in mice deficient in the brain-derived neurotrophic factor (BDNF) gene, as well as in a number of other knockout animals. Despite its power the gene-targeting approach is always fraught with the danger of looking at the cumulative direct and indirect effects of the absence of a particular gene rather than its immediate function. The re-expression of a specific gene at a selective time point and at a specific site in gene-defective mutants presents a potent procedure to overcome this limitation and to evaluate the causal relationship between the absence of a particular gene and the impairment of a function in gene-defective animals. Here we demonstrate that the re-expression of the BDNF gene in the CA1 region almost completely restores the severely impaired LTP in hippocampal slices of BDNF-deficient mice. The results therefore provide strong evidence for the direct involvement of BDNF in the process of LTP.

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Sprache(n): eng - English
 Datum: 1996
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: Anderer: WOS:A1996VP93700090
DOI: 10.1073/pnas.93.22.12547
ISSN: 0027-8424
 Art des Abschluß: -

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Titel: Proceedings of the National Academy of Sciences of the United States of America
  Andere : PNAS
  Andere : Proceedings of the National Academy of Sciences of the USA
  Kurztitel : Proc. Natl. Acad. Sci. U. S. A.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Washington, D.C. : National Academy of Sciences
Seiten: - Band / Heft: 93 (22) Artikelnummer: - Start- / Endseite: 12547 - 12552 Identifikator: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230