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  Wunen, a Drosophila lipid phosphate phosphatase, is required for septate junction mediated barrier function

Renault, A., Ile, K., Tripathy, R., & Goldfinger, V. (2012). Wunen, a Drosophila lipid phosphate phosphatase, is required for septate junction mediated barrier function. In 53rd Annual Drosophila Research Conference 2012 (pp. 165).

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-4349-8 Version Permalink: https://hdl.handle.net/21.11116/0000-000B-4355-A
Genre: Meeting Abstract

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http://www.drosophila-conf.org/2012/book/Abstracts_Web.pdf (Abstract)
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 Creators:
Renault, AD1, Author           
Ile, K1, Author           
Tripathy, R1, Author           
Goldfinger, V1, Author           
Affiliations:
1Research Group Extracellular Lipid Signaling in Drosophila Development, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3390297              

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 Abstract: Lipid phosphate phosphatases (LPPs) are integral membrane enzymes than can regulate the levels of bioactive lipids such as sphingosine 1-phosphate and
lysophosphatidic acid. The Drosophila LPPs wunen (wun) and wunen2 (wun2) have a well-established role in regulating the survival and migration of germ
cells. We now show that Wun has an independent and essential cell autonomous role in development of the trachea. In particular Wun is required to maintain
septate junction (SJ) paracellular barrier function, loss of which causes failure to accumulate critical luminal components. We find the integrity of the blood
brain barrier is also lost in wun mutants indicating a general role for LPPs in SJ function. Furthermore by comparing the rescue ability of different LPP
homologs we show that Wun function in the trachea is distinct from its role in germ cell migration, although in both cases, catalytic activity is essential for function.

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 Dates: 2012-03
 Publication Status: Published online
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Title: 53rd Annual Drosophila Research Conference 2012
Place of Event: Chicago, IL, USA
Start-/End Date: 2012-03-03 - 2012-03-11

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Title: 53rd Annual Drosophila Research Conference 2012
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 124 Start / End Page: 165 Identifier: -