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  Trimeric autotransporter adhesins: variable structure, common function

Linke, D., Riess, T., Autenrieth, I., Lupas, A., & Kempf, V. (2006). Trimeric autotransporter adhesins: variable structure, common function. Trends in Microbiology, 14(6), 264-270. doi:10.1016/j.tim.2006.04.005.

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 Creators:
Linke, D1, Author                 
Riess, T, Author
Autenrieth, IB, Author
Lupas, A1, Author                 
Kempf, VAJ, Author
Affiliations:
1Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3375791              

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 Abstract: Trimeric autotransporter adhesins (TAAs) are important virulence factors in gram-negative pathogens. Despite the variety of hosts ranging from plants to mammals and the specialized regulation of TAAs, their molecular organization follows surprisingly simple rules: they form trimeric surface structures with a head-stalk-anchor architecture. The head and stalk are composed of a small set of domains, building blocks that are frequently arranged repetitively. We propose that this repetitive arrangement facilitates recombination of domains to modulate the specificity of the common function: adhesion to the host.

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 Dates: 2006-06
 Publication Status: Issued
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.tim.2006.04.005
PMID: 16678419
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Title: Trends in Microbiology
Source Genre: Journal
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Publ. Info: Cambridge, UK : Elsevier Current Trends
Pages: - Volume / Issue: 14 (6) Sequence Number: - Start / End Page: 264 - 270 Identifier: ISSN: 0966-842X
CoNE: https://pure.mpg.de/cone/journals/resource/954926244528