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  Lipodystrophic laminopathy: Lamin A mutation relaxes chromatin architecture to impair adipogenesis

Elzeneini, E., & Wickström, S. A. (2017). Lipodystrophic laminopathy: Lamin A mutation relaxes chromatin architecture to impair adipogenesis. J Cell Biol, 216(9), 2607-2610. doi:10.1083/jcb.201707090.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-4F88-4 Version Permalink: https://hdl.handle.net/21.11116/0000-000B-4F89-3
Genre: Journal Article

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https://pubmed.ncbi.nlm.nih.gov/28811278/ (Any fulltext)
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 Creators:
Elzeneini, E., Author
Wickström, S. A.1, Author           
Affiliations:
1Wickström – Skin Homeostasis and Ageing, Max Planck Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_1942298              

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Free keywords: Adipogenesis *Chromatin Lamin Type A/*genetics Lipodystrophy, Familial Partial/genetics Mutation
 Abstract: The familial partial Dunnigan lipodystrophy, characterized by subcutaneous fat loss, is frequently caused by an R482W mutation in lamin A. In this issue, Oldenburg et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701043) demonstrate that this mutation impairs the ability of lamin A to repress the anti-adipogenic miR-335, providing a potential molecular mechanism for the disease.

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Language(s): eng - English
 Dates: 2017-09-042017-08-15
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: 28811278
DOI: 10.1083/jcb.201707090
ISSN: 0021-9525 (Print)0021-9525
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Title: J Cell Biol
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 216 (9) Sequence Number: - Start / End Page: 2607 - 2610 Identifier: -