ausblenden:
Schlagwörter:
Adipogenesis
*Chromatin
Lamin Type A/*genetics
Lipodystrophy, Familial Partial/genetics
Mutation
Zusammenfassung:
The familial partial Dunnigan lipodystrophy, characterized by subcutaneous fat loss, is frequently caused by an R482W mutation in lamin A. In this issue, Oldenburg et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701043) demonstrate that this mutation impairs the ability of lamin A to repress the anti-adipogenic miR-335, providing a potential molecular mechanism for the disease.
