非表示:
キーワード:
Adult
Aged
Aged, 80 and over
Blood Pressure/*genetics
Cardiovascular Diseases/epidemiology/genetics
Cells, Cultured
Female
Genetic Loci
Genetic Predisposition to Disease
Genetic Testing/methods
Genetics, Population/methods
Genome-Wide Association Study
Human Umbilical Vein Endothelial Cells
Humans
Hypertension/genetics
Life Style
Male
Middle Aged
Polymorphism, Single Nucleotide
*Quantitative Trait Loci
Risk Factors
要旨:
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.