Genetic analysis of over 1 million people identifies 535 new loci associated 
with blood pressure traits

Evangelou, E.; Warren, H. R.; Mosen-Ansorena, D.; Mifsud, B.; Pazoki, R.; Gao, H.; Ntritsos, G.; Dimou, N.; Cabrera, C. P.; Karaman, I.; Ng, F. L.; Evangelou, M.; Witkowska, K.; Tzanis, E.; Hellwege, J. N.; Giri, A.; Velez Edwards, D. R.; Sun, Y. V.; Cho, K.; Gaziano, J. M.; Wilson, P. W. F.; Tsao, P. S.; Kovesdy, C. P.; Esko, T.; Magi, R.; Milani, L.; Almgren, P.; Boutin, T.; Debette, S.; Ding, J.; Giulianini, F.; Holliday, E. G.; Jackson, A. U.; Li-Gao, R.; Lin, W. Y.; Luan, J.; Mangino, M.; Oldmeadow, C.; Prins, B. P.; Qian, Y.; Sargurupremraj, M.; Shah, N.; Surendran, P.; Theriault, S.; Verweij, N.; Willems, S. M.; Zhao, J. H.; Amouyel, P.; Connell, J.; de Mutsert, R.; Doney, A. S. F.; Farrall, M.; Menni, C.; Morris, A. D.; Noordam, R.; Pare, G.; Poulter, N. R.; Shields, D. C.; Stanton, A.; Thom, S.; Abecasis, G.; Amin, N.; Arking, D. E.; Ayers, K. L.; Barbieri, C. M.; Batini, C.; Bis, J. C.; Blake, T.; Bochud, M.; Boehnke, M.; Boerwinkle, E.; Boomsma, D. I.; Bottinger, E. P.; Braund, P. S.; Brumat, M.; Campbell, A.; Campbell, H.; Chakravarti, A.; Chambers, J. C.; Chauhan, G.; Ciullo, M.; Cocca, M.; Collins, F.; Cordell, H. J.; Davies, G.; de Borst, M. H.; de Geus, E. J.; Deary, I. J.; Deelen, J.; Wain, L. V.; Elliott, P.; Caulfield, M. J.; Million Veteran, Program

doi:10.1038/s41588-018-0205-x

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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Evangelou, E., Warren, H. R., Mosen-Ansorena, D., Mifsud, B., Pazoki, R., Gao, H., et al. (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet, 50(10), 1412-1425. doi:10.1038/s41588-018-0205-x.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-48A1-E Version Permalink: https://hdl.handle.net/21.11116/0000-000B-48A2-D

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https://www.ncbi.nlm.nih.gov/pubmed/30224653 (Any fulltext) Open Access status unknown

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Evangelou, E., Author
Warren, H. R., Author
Mosen-Ansorena, D., Author
Mifsud, B., Author
Pazoki, R., Author
Gao, H., Author
Ntritsos, G., Author
Dimou, N., Author
Cabrera, C. P., Author
Karaman, I., Author
Ng, F. L., Author
Evangelou, M., Author
Witkowska, K., Author
Tzanis, E., Author
Hellwege, J. N., Author
Giri, A., Author
Velez Edwards, D. R., Author
Sun, Y. V., Author
Cho, K., Author
Gaziano, J. M., Author
Wilson, P. W. F., AuthorTsao, P. S., AuthorKovesdy, C. P., AuthorEsko, T., AuthorMagi, R., AuthorMilani, L., AuthorAlmgren, P., AuthorBoutin, T., AuthorDebette, S., AuthorDing, J., AuthorGiulianini, F., AuthorHolliday, E. G., AuthorJackson, A. U., AuthorLi-Gao, R., AuthorLin, W. Y., AuthorLuan, J., AuthorMangino, M., AuthorOldmeadow, C., AuthorPrins, B. P., AuthorQian, Y., AuthorSargurupremraj, M., AuthorShah, N., AuthorSurendran, P., AuthorTheriault, S., AuthorVerweij, N., AuthorWillems, S. M., AuthorZhao, J. H., AuthorAmouyel, P., AuthorConnell, J., Authorde Mutsert, R., AuthorDoney, A. S. F., AuthorFarrall, M., AuthorMenni, C., AuthorMorris, A. D., AuthorNoordam, R., AuthorPare, G., AuthorPoulter, N. R., AuthorShields, D. C., AuthorStanton, A., AuthorThom, S., AuthorAbecasis, G., AuthorAmin, N., AuthorArking, D. E., AuthorAyers, K. L., AuthorBarbieri, C. M., AuthorBatini, C., AuthorBis, J. C., AuthorBlake, T., AuthorBochud, M., AuthorBoehnke, M., AuthorBoerwinkle, E., AuthorBoomsma, D. I., AuthorBottinger, E. P., AuthorBraund, P. S., AuthorBrumat, M., AuthorCampbell, A., AuthorCampbell, H., AuthorChakravarti, A., AuthorChambers, J. C., AuthorChauhan, G., AuthorCiullo, M., AuthorCocca, M., AuthorCollins, F., AuthorCordell, H. J., AuthorDavies, G., Authorde Borst, M. H., Authorde Geus, E. J., AuthorDeary, I. J., AuthorDeelen, J.¹, Author Wain, L. V., AuthorElliott, P., AuthorCaulfield, M. J., AuthorMillion Veteran, Program, Author more..

Affiliations:
1Deelen – Genetics and Biomarkers of Human Ageing, Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_3394006

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Free keywords: Adult Aged Aged, 80 and over Blood Pressure/*genetics Cardiovascular Diseases/epidemiology/genetics Cells, Cultured Female Genetic Loci Genetic Predisposition to Disease Genetic Testing/methods Genetics, Population/methods Genome-Wide Association Study Human Umbilical Vein Endothelial Cells Humans Hypertension/genetics Life Style Male Middle Aged Polymorphism, Single Nucleotide *Quantitative Trait Loci Risk Factors

Abstract: High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

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Dates: Published Online: 2018-10Date issued: 2018-09-19

Publication Status: Issued

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Identifiers: Other: 30224653
DOI: 10.1038/s41588-018-0205-x
ISSN: 1546-1718 (Electronic)1061-4036 (Linking)

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Title: Nat Genet

Source Genre: Journal

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Pages: - Volume / Issue: 50 (10) Sequence Number: - Start / End Page: 1412 - 1425 Identifier: -