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Free keywords:
Drosophila
Parkin
Parkinson's disease
Pink1
circadian rhythms
endoplasmic reticulum
mitochondria
sleep
Abstract:
Parkinson's disease patients report sleep disturbances well ahead of motor symptoms. In this issue of Neuron, Valadas et al. (2018) report that the disease genes pink1 and parkin exert novel, cell-type-specific effects to modulate ER-mitochondria contacts, neuropeptidergic transmission, and sleep patterns.