Swallow tail sign and nigrosome 1: Close but not quite the same

Brammerloh, Malte; Kirilina, Evgeniya; Alkemade, Anneke; Bazin, Pierre-Louis; Jantzen, Caroline; Jäger, Carsten; Herrler, Andreas; Gowland, Penny A.; Forstmann, Birte; Pine, Kerrin; Morawski, Markus; Weiskopf, Nikolaus

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Swallow tail sign and nigrosome 1: Close but not quite the same

Brammerloh, M., Kirilina, E., Alkemade, A., Bazin, P.-L., Jantzen, C., Jäger, C., et al. (2021). Swallow tail sign and nigrosome 1: Close but not quite the same. In Proceedings of the ISMRM & SMRT Annual Meeting & Exhibition.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-4AD1-6 Version Permalink: https://hdl.handle.net/21.11116/0000-000B-4AFF-4

Genre: Conference Paper

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Brammerloh, Malte¹, Author
Kirilina, Evgeniya¹, Author
Alkemade, Anneke, Author
Bazin, Pierre-Louis², Author
Jantzen, Caroline, Author
Jäger, Carsten¹, Author
Herrler, Andreas, Author
Gowland, Penny A., Author
Forstmann, Birte, Author
Pine, Kerrin¹, Author
Morawski, Markus¹, Author
Weiskopf, Nikolaus¹, Author

Affiliations:
1Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549

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Abstract: MRI-based quantification of dopaminergic neurons (DN) and their neuromelanin (NM) in substantia nigra (SN) has great potential to serve as a specific biomarker for neurodegeneration in movement disorders. We used 22-µm-resolution post mortem MR microscopy combined with ion beam microscopy to characterize the magnetic properties of DN. MR microscopy visualized individual DN and provided 3D cellular maps of the entire SN. Static dephasing was determined as main effective transverse relaxation mechanism of DN. We characterized the susceptibility of iron in DN and estimated that the contribution of DN to R2* and QSM may also be detected with in vivo MRI.

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Dates: Date issued: 2021

Publication Status: Issued

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Identifiers: BibTex Citekey: brammerloh_swallow_2021

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Title: Proceedings of the ISMRM & SMRT Annual Meeting & Exhibition

Source Genre: Proceedings

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Pages: - Volume / Issue: 29 Sequence Number: 3024 Start / End Page: - Identifier: -