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  Neandertal introgression partitions the genetic landscape of neuropsychiatric disorders and associated behavioral phenotypes

Dannemann, M., Milaneschi, Y., Yermakovich, D., Stiglbauer, V., Kariis, H. M., Krebs, K., et al. (2022). Neandertal introgression partitions the genetic landscape of neuropsychiatric disorders and associated behavioral phenotypes. Translational Psychiatry, 12: 433. doi:10.1038/s41398-022-02196-2.

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 Creators:
Dannemann, Michael1, 2, Author                 
Milaneschi, Yuri, Author
Yermakovich, Danat, Author
Stiglbauer, Victoria, Author
Kariis, Hanna Maria, Author
Krebs, Kristi, Author
Friese, Manuel A., Author
Otte, Christian, Author
Esko, Tõnu, Author
Metspalu, Andres, Author
Milani, Lili, Author
Mägi, Reedik, Author
Nelis, Mari, Author
Lehto, Kelli, Author
Penninx, Brenda W. J. H., Author
Kelso, Janet1, 2, Author
Gold, Stefan M., Author
Team, Estonian Biobank Research, Author
Affiliations:
1The Minerva Research Group for Bioinformatics, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, ou_2074303              
2Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, ou_1497672              

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 Abstract: Despite advances in identifying the genetic basis of psychiatric and neurological disorders, fundamental questions about their evolutionary origins remain elusive. Here, introgressed variants from archaic humans such as Neandertals can serve as an intriguing research paradigm. We compared the number of associations for Neandertal variants to the number of associations of frequency-matched non-archaic variants with regard to human CNS disorders (neurological and psychiatric), nervous system drug prescriptions (as a proxy for disease), and related, non-disease phenotypes in the UK biobank (UKBB). While no enrichment for Neandertal genetic variants were observed in the UKBB for psychiatric or neurological disease categories, we found significant associations with certain behavioral phenotypes including pain, chronotype/sleep, smoking and alcohol consumption. In some instances, the enrichment signal was driven by Neandertal variants that represented the strongest association genome-wide. SNPs within a Neandertal haplotype that was associated with smoking in the UKBB could be replicated in four independent genomics datasets.

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Language(s): eng - English
 Dates: 2022-10-05
 Publication Status: Published online
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41398-022-02196-2
 Degree: -

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Title: Translational Psychiatry
Source Genre: Journal
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Publ. Info: Springer Nature Publishing Group
Pages: - Volume / Issue: 12 Sequence Number: 433 Start / End Page: - Identifier: ISBN: 2158-3188