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  Effects of a metabotropic glutamate agonist, trans-ACPD, on cortical epileptiform activity

Taschenberger, H., Roy, B. L., & Lowe, D. A. (1992). Effects of a metabotropic glutamate agonist, trans-ACPD, on cortical epileptiform activity. NeuroReport, 3(7), 629-632. doi:10.1097/00001756-199207000-00022.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-5080-9 Version Permalink: https://hdl.handle.net/21.11116/0000-000B-523E-4
Genre: Journal Article

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Effects_of_a_metabotropic_glutamate_agonist,.22.pdf (Publisher version), 306KB
 
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 Creators:
Taschenberger, Holger1, Author                 
Roy, B. L., Author
Lowe, D. A., Author
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1External Organizations, ou_persistent22              

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 Abstract: The effect of the metabotropic glutamate receptor agonist trans-l-amino-1,3,cyclopentanedicarboxylic acid (trans-ACPD) on epileptiform activity induced in rat neocortical slices by exposure to Mg2+-free medium was examined. Trans-ACPD dose-dependently (10–200 $mUM) decreased the frequency of spontaneous epileptiform events whilst increasing both the duration of afterpotentials and the number of afterbursts associated with single events. This effect on afterpotentials and afterbursting was particularly pronounced in 14–17 day-old rats and was blocked by the sigma ligand ditolyguanidine (DTG) 10 $mUM. The putative metabotropic glutamate receptor antagonist l-AP3 did not antagonise the actions of trans-ACPD. The results suggest a role for metabotropic glutamate receptors in epilepsy, possibly in the transition from interictal to ictal activity.

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Language(s): eng - English
 Dates: 1992
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: 10.1097/00001756-199207000-00022
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Title: NeuroReport
Source Genre: Journal
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Publ. Info: Oxford, UK : Rapid Communications of Oxford Ltd.
Pages: - Volume / Issue: 3 (7) Sequence Number: - Start / End Page: 629 - 632 Identifier: ISSN: 0959-4965
CoNE: https://pure.mpg.de/cone/journals/resource/954925578070