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  Socioeconomic inequalities in cognitive functioning only to a small extent attributable to modifiable health and lifestyle factors in individuals without dementia

Röhr, S., Pabst, A., Baber, R., Engel, C., Glaesmer, H., Hinz, A., et al. (2022). Socioeconomic inequalities in cognitive functioning only to a small extent attributable to modifiable health and lifestyle factors in individuals without dementia. Journal of Alzheimer's Disease, 90(4), 1523-1534. doi:10.3233/JAD-220474.

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 Urheber:
Röhr, Susanne1, 2, 3, Autor
Pabst, Alexander1, Autor
Baber, Ronny4, 5, Autor
Engel, Christoph5, 6, Autor
Glaesmer, Heide7, Autor
Hinz, Andreas7, Autor
Schroeter, Matthias L.8, 9, Autor           
Witte, A. Veronica8, Autor                 
Zeynalova, Samira5, 6, Autor
Villringer, Arno8, 9, Autor                 
Löffler, Markus5, 6, Autor
Riedel-Heller, Steffi G.1, Autor
Affiliations:
1Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
2Global Brain Health Institute (GBHI), Trinity College Dublin, Ireland, ou_persistent22              
3School of Psychology, Massey University, Palmerston North, New Zealand, ou_persistent22              
4Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
5Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
6Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              
7Department of Medical Psychology and Medical Sociology, University of Leipzig, Germany, ou_persistent22              
8Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
9Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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Schlagwörter: Cognitive function; Dementia; Epidemiology; Lifestyle; Prevention; Public health; Risk factors; Social inequalities; Socioeconomic status
 Zusammenfassung: Background: There are socioeconomic inequalities in dementia risk. Underlying pathways are not well known.

Objective: To investigate whether modifiable health and lifestyle factors for brain health mediate the association of socioeconomic status (SES) and cognitive functioning in a population without dementia.

Methods: The "LIfestyle for BRAin health" (LIBRA) score was computed for 6,203 baseline participants of the LIFE-Adult-Study. LIBRA predicts dementia in midlife and early late life, based on 12 modifiable factors. Associations of SES (education, net equivalence income, and occupational status) and LIBRA with cognitive functioning (composite score) were investigated using adjusted linear regression models. Bootstrapped structural equation modelling (SEM) was used to investigate whether LIBRA mediated the association of SES and cognitive functioning.

Results: Participants were M = 57.4 (SD = 10.6, range: 40-79) years old; 50.3% were female. Both, SES (Wald: F(2)=52.5, p < 0.001) and LIBRA (Wald: F(1)=5.9, p < 0.05) were independently associated with cognitive functioning; there was no interaction (Wald: F(2)=2.9, p = 0.060). Lower SES and higher LIBRA scores indicated lower cognitive functioning. LIBRA partially mediated the association of SES and cognitive functioning (IE: =0.02, 95% CI [0.02, 0.03], p < 0.001). The proportion mediated was 12.7%.

Conclusion: Differences in cognitive functioning due to SES can be partially attributed to differences in modifiable health and lifestyle factors; but to a small extent. This suggests that lifestyle interventions could attenuate socioeconomic inequalities in cognitive functioning. However, directly intervening on the social determinants of health may yield greater benefits for dementia risk reduction.

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Sprache(n): eng - English
 Datum: 2022-09-192022-10-182022-12
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.3233/JAD-220474
PMID: 36278347
 Art des Abschluß: -

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Förderorganisation : European Commission (EC)
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Förderorganisation : Free State of Saxony
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Förderorganisation : Global Brain Health Institute (GBHI)
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Förderorganisation : Hand and Ilse Breuer Foundation

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Titel: Journal of Alzheimer's Disease
  Kurztitel : J. Alzheimers Dis.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Amsterdam : IOS Press
Seiten: - Band / Heft: 90 (4) Artikelnummer: - Start- / Endseite: 1523 - 1534 Identifikator: ISSN: 1387-2877
CoNE: https://pure.mpg.de/cone/journals/resource/1387-2877