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  Associations between abdominal adipose tissue, reproductive span, and brain characteristics in post-menopausal women

Schindler, L. S., Subramaniapillai, S., Barth, C., van der Meer, D., Pedersen, M. L., Kaufmann, T., et al. (2022). Associations between abdominal adipose tissue, reproductive span, and brain characteristics in post-menopausal women. NeuroImage: Clinical, 26: 103239. doi:10.1016/j.nicl.2022.103239.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000B-5468-2 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000D-12CE-7
Genre: Zeitschriftenartikel

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 Urheber:
Schindler, Louise S.1, 2, Autor
Subramaniapillai, Sivaniya1, 2, Autor
Barth, Claudia3, 4, Autor
van der Meer, Dennis3, 5, Autor
Pedersen, Mads L.2, 3, Autor
Kaufmann, Tobias3, 6, Autor
Maximov, Ivan I.3, 7, Autor
Linge, Jennifer8, 9, Autor
Leinhard, Olof Dahlqvist8, 9, 10, Autor
Beck, Dani2, 3, Autor
Gurholt, Tiril P.3, Autor
Voldsbekk, Irene2, 3, Autor
Suri, Sana11, 12, Autor
Ebmeier, Klaus P.11, Autor
Draganski, Bogdan1, 13, Autor           
Andreassen, Ole A.3, 14, Autor
de Lange, Ann-Marie G.1, 2, 11, Autor
Affiliations:
1Département des Neurosciences Cliniques, Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
2Department of Psychology, University of Oslo, Norway, ou_persistent22              
3NORMENT Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Norway, ou_persistent22              
4Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway, ou_persistent22              
5School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, the Netherlands, ou_persistent22              
6Department for Psychiatry and Psychotherapy, Eberhard Karls University Tübingen, Germany, ou_persistent22              
7Department of Health and Functioning, Western Norway University of Applied Sciences, Bergen, Norway, ou_persistent22              
8AMRA Medical AB, Linköping, Sweden, ou_persistent22              
9Department of Health, Medicine, and Caring Sciences, Linköping University, Sweden, ou_persistent22              
10Center for Medical Image Science and Visualization (CMIV), Linköping University, Sweden, ou_persistent22              
11Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
12Wellcome Centre For Integrative Neuroimaging, University of Oxford, United Kingdom, ou_persistent22              
13Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
14K.G. Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Norway, ou_persistent22              

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Schlagwörter: Brain age; White matter hyperintensities; Adipose tissue; Cardiometabolic health; Body MRI; Menopause; Reproductive span; Polygenic scores; UK Biobank
 Zusammenfassung: The menopause transition involves changes in oestrogens and adipose tissue distribution, which may influence female brain health post-menopause. Although increased central fat accumulation is linked to risk of cardiometabolic diseases, adipose tissue also serves as the primary biosynthesis site of oestrogens post-menopause. It is unclear whether different types of adipose tissue play diverging roles in female brain health post-menopause, and whether this depends on lifetime oestrogen exposure, which can have lasting effects on the brain and body even after menopause. Using the UK Biobank sample, we investigated associations between brain characteristics and visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (ASAT) in 10,251 post-menopausal females, and assessed whether the relationships varied depending on length of reproductive span (age at menarche to age at menopause). To parse the effects of common genetic variation, we computed polygenic scores for reproductive span. The results showed that higher VAT and ASAT were both associated with higher grey and white matter brain age, and greater white matter hyperintensity load. The associations varied positively with reproductive span, indicating more prominent associations between adipose tissue and brain measures in females with a longer reproductive span. The effects were in general small, but could not be fully explained by genetic variation or relevant confounders. Our findings indicate that associations between abdominal adipose tissue and brain health post-menopause may partly depend on individual differences in cumulative oestrogen exposure during reproductive years, emphasising the complexity of neural and endocrine ageing processes in females.

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Sprache(n): eng - English
 Datum: 2022-10-062022-07-262022-10-172022-10-262022
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1016/j.nicl.2022.103239
Anderer: epub 2022
PMID: 36451350
 Art des Abschluß: -

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Projektname : -
Grant ID : 32003B_135679; 32003B_159780; 324730_192755; CRSK-3_190185
Förderprogramm : -
Förderorganisation : Swiss National Science Foundation (SNSF)
Projektname : -
Grant ID : 276082; 323961; 273345; 249795; 298646; 300768; 250358; 223273; 283799; 283798
Förderprogramm : -
Förderorganisation : Research Council of Norway
Projektname : -
Grant ID : 2018076; 2019101; 2017112; 2022080
Förderprogramm : -
Förderorganisation : South-Eastern Norway Regional Health Authority
Projektname : -
Grant ID : 802998; 732592; 847776
Förderprogramm : Horizon 2020
Förderorganisation : European Research Council (ERC)
Projektname : -
Grant ID : 1117747
Förderprogramm : -
Förderorganisation : HDH Wills 1965 Charitable Trust
Projektname : -
Grant ID : 203139/Z/16/Z
Förderprogramm : -
Förderorganisation : Wellcome Trust
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Leenaards Foundation
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Natural Sciences and Engineering Research Council of Canada (NSERC)
Projektname : -
Grant ID : 441
Förderprogramm : -
Förderorganisation : Alzheimer’s Society

Quelle 1

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Titel: NeuroImage: Clinical
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Elsevier
Seiten: - Band / Heft: 26 Artikelnummer: 103239 Start- / Endseite: - Identifikator: ISSN: 2213-1582
CoNE: https://pure.mpg.de/cone/journals/resource/2213-1582