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  Associations between abdominal adipose tissue, reproductive span, and brain characteristics in post-menopausal women

Schindler, L. S., Subramaniapillai, S., Barth, C., van der Meer, D., Pedersen, M. L., Kaufmann, T., et al. (2022). Associations between abdominal adipose tissue, reproductive span, and brain characteristics in post-menopausal women. NeuroImage: Clinical, 26: 103239. doi:10.1016/j.nicl.2022.103239.

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Schindler, Louise S.1, 2, Author
Subramaniapillai, Sivaniya1, 2, Author
Barth, Claudia3, 4, Author
van der Meer, Dennis3, 5, Author
Pedersen, Mads L.2, 3, Author
Kaufmann, Tobias3, 6, Author
Maximov, Ivan I.3, 7, Author
Linge, Jennifer8, 9, Author
Leinhard, Olof Dahlqvist8, 9, 10, Author
Beck, Dani2, 3, Author
Gurholt, Tiril P.3, Author
Voldsbekk, Irene2, 3, Author
Suri, Sana11, 12, Author
Ebmeier, Klaus P.11, Author
Draganski, Bogdan1, 13, Author           
Andreassen, Ole A.3, 14, Author
de Lange, Ann-Marie G.1, 2, 11, Author
1Département des Neurosciences Cliniques, Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
2Department of Psychology, University of Oslo, Norway, ou_persistent22              
3NORMENT Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Norway, ou_persistent22              
4Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway, ou_persistent22              
5School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, the Netherlands, ou_persistent22              
6Department for Psychiatry and Psychotherapy, Eberhard Karls University Tübingen, Germany, ou_persistent22              
7Department of Health and Functioning, Western Norway University of Applied Sciences, Bergen, Norway, ou_persistent22              
8AMRA Medical AB, Linköping, Sweden, ou_persistent22              
9Department of Health, Medicine, and Caring Sciences, Linköping University, Sweden, ou_persistent22              
10Center for Medical Image Science and Visualization (CMIV), Linköping University, Sweden, ou_persistent22              
11Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
12Wellcome Centre For Integrative Neuroimaging, University of Oxford, United Kingdom, ou_persistent22              
13Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
14K.G. Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Norway, ou_persistent22              


Free keywords: Brain age; White matter hyperintensities; Adipose tissue; Cardiometabolic health; Body MRI; Menopause; Reproductive span; Polygenic scores; UK Biobank
 Abstract: The menopause transition involves changes in oestrogens and adipose tissue distribution, which may influence female brain health post-menopause. Although increased central fat accumulation is linked to risk of cardiometabolic diseases, adipose tissue also serves as the primary biosynthesis site of oestrogens post-menopause. It is unclear whether different types of adipose tissue play diverging roles in female brain health post-menopause, and whether this depends on lifetime oestrogen exposure, which can have lasting effects on the brain and body even after menopause. Using the UK Biobank sample, we investigated associations between brain characteristics and visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (ASAT) in 10,251 post-menopausal females, and assessed whether the relationships varied depending on length of reproductive span (age at menarche to age at menopause). To parse the effects of common genetic variation, we computed polygenic scores for reproductive span. The results showed that higher VAT and ASAT were both associated with higher grey and white matter brain age, and greater white matter hyperintensity load. The associations varied positively with reproductive span, indicating more prominent associations between adipose tissue and brain measures in females with a longer reproductive span. The effects were in general small, but could not be fully explained by genetic variation or relevant confounders. Our findings indicate that associations between abdominal adipose tissue and brain health post-menopause may partly depend on individual differences in cumulative oestrogen exposure during reproductive years, emphasising the complexity of neural and endocrine ageing processes in females.


Language(s): eng - English
 Dates: 2022-10-062022-07-262022-10-172022-10-262022
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.nicl.2022.103239
Other: epub 2022
PMID: 36451350
 Degree: -



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Grant ID : 32003B_135679; 32003B_159780; 324730_192755; CRSK-3_190185
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Funding organization : Swiss National Science Foundation (SNSF)
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Grant ID : 276082; 323961; 273345; 249795; 298646; 300768; 250358; 223273; 283799; 283798
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Funding organization : Research Council of Norway
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Grant ID : 2018076; 2019101; 2017112; 2022080
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Funding organization : South-Eastern Norway Regional Health Authority
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Grant ID : 802998; 732592; 847776
Funding program : Horizon 2020
Funding organization : European Research Council (ERC)
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Grant ID : 1117747
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Funding organization : HDH Wills 1965 Charitable Trust
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Grant ID : 203139/Z/16/Z
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Funding organization : Wellcome Trust
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Funding organization : Leenaards Foundation
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Funding organization : Natural Sciences and Engineering Research Council of Canada (NSERC)
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Grant ID : 441
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Funding organization : Alzheimer’s Society

Source 1

Title: NeuroImage: Clinical
Source Genre: Journal
Publ. Info: Elsevier
Pages: - Volume / Issue: 26 Sequence Number: 103239 Start / End Page: - Identifier: ISSN: 2213-1582
CoNE: https://pure.mpg.de/cone/journals/resource/2213-1582