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  The linkage-disequilibrium and recombinational landscape in Daphnia pulex

Lynch, M., Ye, Z., Urban, L., Maruki, T., & Wei, W. (2022). The linkage-disequilibrium and recombinational landscape in Daphnia pulex. Genome Biology and Evolution, 14(11): evac145. doi:10.1093/gbe/evac145.

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 Urheber:
Lynch, Michael, Autor
Ye, Zhiqiang, Autor
Urban, Lina1, Autor           
Maruki, Takahiro, Autor
Wei, Wen, Autor
Lohmueller, Kirk, Herausgeber
Affiliations:
1Research Group Bioinformatics (Haubold), Department Evolutionary Genetics (Tautz), Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445644              

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Schlagwörter: recombination, Daphnia, linkage disequilibrium, gene conversion, population genomics
 Zusammenfassung: By revealing the inuence of recombinational activity beyond what can be achieved with controlled crosses, measures of linkage disequilibrium (LD) in natural populations provide a powerful means of defining the recombinational landscape within which genes evolve. In one of the most comprehensive studies of this sort ever performed, involving whole-genome analyses on nearly 1000 individuals of the cyclically parthenogenetic microcrustacean Daphnia pulex, the data suggest a relatively uniform pattern of recombination across the genome. Patterns of LD are quite consistent among populations; average rates of recombination are quite similar for all chromosomes; and although some chromosomal regions have elevated recombination rates, the degree of ination is not large, and the overall spatial pattern of recombination is close to the random expectation. Contrary to expectations for models in which crossing-over is the primary mechanism of recombination, and consistent with data for other species, the distancedependent pattern of LD indicates excessively high levels at both short and long distances and unexpectedly low levels of decay at long distances, suggesting significant roles for factors such as nonindependent mutation, population subdivision, and recombination mechanisms unassociated with crossing over. These observations raise issues regarding the classical LD equilibrium model widely applied in population genetics to infer recombination rates across various length scales on chromosomes.

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Sprache(n): eng - English
 Datum: 2022-09-152021-05-182022-09-202022-09-282022-11
 Publikationsstatus: Erschienen
 Seiten: 44
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1093/gbe/evac145
 Art des Abschluß: -

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Titel: Genome Biology and Evolution
  Andere : GBE
  Kurztitel : Genome Biol Evol
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: Oxford : Oxford Univ. Press
Seiten: - Band / Heft: 14 (11) Artikelnummer: evac145 Start- / Endseite: - Identifikator: ISSN: 1759-6653
CoNE: https://pure.mpg.de/cone/journals/resource/1759-6653