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キーワード:
Algorithms
Animals
Blindness/psychology
Data Interpretation, Statistical
Electrophysiological Phenomena
Eye Movements/physiology
Female
Fixation, Ocular
Longitudinal Studies
Macaca mulatta
Magnetic Resonance Imaging
Motion Perception/*physiology
Photic Stimulation
Psychomotor Performance/physiology
Scotoma/physiopathology
Space Perception/physiology
Visual Cortex/*physiology
Visual Pathways/physiology
Visual Perception/physiology
要旨:
Neurons in cortical ventral-stream area V4 are thought to contribute to important aspects of visual processing by integrating information from primary visual cortex (V1). However, how V4 neurons respond to visual stimulation after V1 injury remains unclear: While electrophysiological investigation of V4 neurons during reversible V1 inactivation suggests that virtually all responses are eliminated (Girard et al., 1991), fMRI in humans and monkeys with permanent lesions shows reliable V1-independent activity (Baseler et al., 1999; Goebel et al., 2001; Schmid et al., 2010). To resolve this apparent discrepancy, we longitudinally assessed neuronal functions of macaque area V4 using chronically implanted electrode arrays before and after creating a permanent aspiration lesion in V1. During the month after lesioning, we observed weak yet significant spiking activity in response to stimuli presented to the lesion-affected part of the visual field. These V1-independent responses showed sensitivity for motion and likely reflect the effect of V1-bypassing geniculate input into extrastriate areas.
