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  Enhancement of human NK and LAK cytotoxicity against HCMV-infected cells by rhamnogalacturonan: specificity of reaction

Steinmassl, M., & Anderer, F. (1996). Enhancement of human NK and LAK cytotoxicity against HCMV-infected cells by rhamnogalacturonan: specificity of reaction. Viral Immunology, 9(1), 27-34. doi:10.1089/vim.1996.9.27.

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 Creators:
Steinmassl, M1, Author           
Anderer, FA1, Author           
Affiliations:
1Anderer Group, Friedrich Miescher Laboratory, Max Planck Society, ou_3470951              

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 Abstract: Human peripheral blood mononuclear cells (PBMC) and their subpopulations obtained from healthy donors were used to study improvement of MHC-unrestricted cytotoxic reactions against cells infected with human cytomegalovirus (HCMV) at different multiplicities of infection. Natural killer (NK) and lymphokine-activated killer (LAK) cytotoxicity against HCMV-infected cells was greatly enhanced in the presence of rhamnogalacturonan (500 ng/ml). The increase of the multiplicity of infection from MOI 0.1 to 1.0 had only a slight effect on cytotoxicity enhancement by rhamnogalacturonan. The chemical specificity of interaction of rhamnogalacturonan with effector cells and virus-infected cells was found to be analogous to the interaction with tumor cells, i.e., both types of target cells must express a receptor for rhamnogalacturonan since rhamnogalacturonan-mediated enhancement of NK and LAK cytotoxicity against HCMV-infected cells was similarly inhibited by preincubation of CD56+ effector cells with 60% deacetylated D-mannose pentaacetate.

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 Dates: 1996-03
 Publication Status: Issued
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1089/vim.1996.9.27
PMID: ax8733917
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Title: Viral Immunology
  Other : Viral Immunol.
Source Genre: Journal
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Affiliations:
Publ. Info: New York, NY : Mary Ann Liebert
Pages: - Volume / Issue: 9 (1) Sequence Number: - Start / End Page: 27 - 34 Identifier: ISSN: 0882-8245
CoNE: https://pure.mpg.de/cone/journals/resource/954925548316