ausblenden:
Schlagwörter:
Animals
Caenorhabditis elegans
*Caenorhabditis elegans Proteins
Cell Death/genetics/*physiology
Forkhead Transcription Factors
Gene Silencing
Longevity/genetics/*physiology
Sirtuins/metabolism/*physiology
Transcription Factors/*physiology
Tumor Suppressor Protein p53/metabolism
Zusammenfassung:
Genetic experiments in C. elegans suggested that SIR2, an NAD-dependent protein deacetylase, acts through FOXO/DAF-16 transcription factor to prolong life. Recent studies show that mammalian SIR2 deacetylates FOXO, and may maximize survival by tempering cell death and increasing stress resistance.