English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
 Local TagsRelease HistoryDetailsSummary
  Hexosamine pathway and (ER) protein quality control

Denzel, M. S., & Antebi, A. (2014). Hexosamine pathway and (ER) protein quality control. Curr Opin Cell Biol, 33, 14-8. doi:10.1016/j.ceb.2014.10.001.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-000B-A354-E Version Permalink: https://hdl.handle.net/21.11116/0000-000B-A355-D
Genre: Journal Article

Files

show Files

Locators

show
hide
Locator:
https://www.ncbi.nlm.nih.gov/pubmed/25463841 (Any fulltext)
Description:
-
OA-Status:
Not specified

Creators

show
hide
 Creators:
Denzel, M. S.1, Author           
Antebi, A.2, Author           
Affiliations:
1Denzel – Metabolic and Genetic Regulation of Ageing, Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_3394008              
2Department Antebi - Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_1942285              

Content

show
hide
Free keywords: Aging/metabolism Animals Endoplasmic Reticulum/*metabolism Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)/metabolism Glycosylation Hexosamines/*metabolism Homeostasis Humans Longevity Proteins/*metabolism Stress, Physiological Unfolded Protein Response Uridine Diphosphate N-Acetylglucosamine/metabolism
 Abstract: Aminosugars produced in the hexosamine pathway (HP) are utilized in protein glycosylation reactions involved in protein maturation and cellular signaling. Recent evidence revealed a role of the HP in protein quality control and ageing. Elevation of the HP product UDP-N-acetylglucosamine in the nematode Caenorhabditis elegans results in resistance towards toxic aggregation-prone proteins, and extended lifespan. Glutamine-fructose 6 phosphate aminotransferase (GFAT-1), the HP's key enzyme, is a target of the unfolded protein response (UPR). Thus, cardiac stress in mice results in GFAT-1 activation that triggers a cytoprotective response. Feeding of glucosamine to aged mice increases their life expectancy. Here we discuss HP activation and cellular protein quality control mechanisms that result in stress resistance and suppression of age-related proteotoxicity.

Details

show
hide
Language(s):
 Dates: 2015-042014-12-03
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: 25463841
DOI: 10.1016/j.ceb.2014.10.001
ISSN: 0955-0674
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Curr Opin Cell Biol
  Alternative Title : Current opinion in cell biology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 33 Sequence Number: - Start / End Page: 14 - 8 Identifier: -