Structure casts light on mtDNA replication

Falkenberg, M.; Larsson, N.G.

doi:10.1016/j.cell.2009.09.030

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Structure casts light on mtDNA replication

Falkenberg, M., & Larsson, N. (2009). Structure casts light on mtDNA replication. Cell, 139(2), 231-3. doi:10.1016/j.cell.2009.09.030.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-9DBD-0 Version Permalink: https://hdl.handle.net/21.11116/0000-000B-9DBE-F

Genre: Journal Article

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Falkenberg, M., Author
Larsson, N.G.¹, Author

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1Department Larsson - Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_1942286

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Free keywords: *DNA Replication DNA, Mitochondrial/*metabolism DNA-Directed DNA Polymerase/*chemistry Humans Mitochondria/genetics/metabolism

Abstract: In this issue, Lee et al. (2009) present a crystal structure of the human mitochondrial DNA polymerase (POLgamma). The structure of this heterotrimeric enzyme lays a foundation for understanding how POLgamma mutations cause human mitochondrial disease and why some antiviral nucleoside analogs cause cellular toxicity.

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Dates: Published Online: 2009-10-16Published in Print: 2009-10-20

Publication Status: Published in print

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Identifiers: Other: 19837028
DOI: 10.1016/j.cell.2009.09.030
ISSN: 0092-8674

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Title: Cell

Alternative Title : Cell

Source Genre: Journal

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Pages: - Volume / Issue: 139 (2) Sequence Number: - Start / End Page: 231 - 3 Identifier: -