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Animals
Apoptosis Inducing Factor/deficiency
Diabetes Mellitus/prevention & control
Insulin Resistance
Mice
Mitochondria/drug effects/metabolism
Obesity/prevention & control
Organ Specificity/drug effects
*Oxidative Phosphorylation
Abstract:
In this issue, Pospisilik et al. (2007) demonstrate that a reduction in mitochondrial oxidative phosphorylation protects mice against obesity and diabetes. This finding suggests that the moderate deficiency in oxidative phosphorylation that is observed in peripheral tissues of insulin-resistant humans is not a causative factor in diabetes but may instead be a compensatory response.
