ausblenden:
Schlagwörter:
Animals
DNA-Binding Proteins/genetics/metabolism
DNA-Directed RNA Polymerases/metabolism
Humans
Mammals/*genetics
Mitochondria/*genetics/metabolism
Mitochondrial Proteins/genetics/metabolism
Nuclear Proteins/genetics/metabolism
Transcription Factors/genetics/metabolism
*Transcription, Genetic
Zusammenfassung:
Initiation of transcription at mitochondrial promoters in mammalian cells requires the simultaneous presence of a monomeric mitochondrial RNA polymerase, mitochondrial transcription factor A, and either transcription factor B1 or B2. We here review recent progress in our understanding of how these basal factors cooperate in the initiation and regulation of mitochondrial transcription. We describe the evolutionary origin of individual transcription factors and discuss how these phylogenetic relationships may facilitate a molecular understanding of the mitochondrial transcription machinery.
