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  Syntheses and biological evaluation of B-ring-modified analogues of dafachronic acid A

Giroux, S., Bethke, A., Fielenbach, N., Antebi, A., & Corey, E. J. (2008). Syntheses and biological evaluation of B-ring-modified analogues of dafachronic acid A. Org Lett, 10(16), 3643-5. doi:10.1021/ol801425v.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-9D7D-9 Version Permalink: https://hdl.handle.net/21.11116/0000-000B-9D7E-8
Genre: Journal Article

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http://www.ncbi.nlm.nih.gov/pubmed/18642835 (Any fulltext)
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 Creators:
Giroux, S., Author
Bethke, A., Author
Fielenbach, N., Author
Antebi, A.1, Author           
Corey, E. J., Author
Affiliations:
1Department Antebi - Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_1942285              

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Free keywords: Animals Caenorhabditis elegans/genetics Caenorhabditis elegans Proteins/chemistry/*drug effects/genetics Ergosterol/*analogs & derivatives/chemical synthesis/chemistry/pharmacology Ligands Molecular Conformation Receptors, Cytoplasmic and Nuclear/chemistry/*drug effects/genetics Stereoisomerism Transcription, Genetic/drug effects/genetics
 Abstract: Synthesis and testing of dafachronic acid A ( 1) and its derivatives 2 and 3 have revealed that 1, and not a further oxidation product, is the natural ligand for the DAF-12 receptor of Caenorhabditis elegans.

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 Dates: 2008
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1021/ol801425v
ISSN: 1523-7052 (Electronic) 1523-7052 (Linking)
 Degree: -

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Title: Org Lett
Source Genre: Journal
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Pages: - Volume / Issue: 10 (16) Sequence Number: - Start / End Page: 3643 - 5 Identifier: -