English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
 Local TagsRelease HistoryDetailsSummary
  Mutation of C. elegans demethylase spr-5 extends transgenerational longevity

Greer, E. L., Becker, B., Latza, C., Antebi, A., & Shi, Y. (2015). Mutation of C. elegans demethylase spr-5 extends transgenerational longevity. Cell Res, 26(2), 229-38. doi:10.1038/cr.2015.148.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-000B-9D73-3 Version Permalink: https://hdl.handle.net/21.11116/0000-000B-9D74-2
Genre: Journal Article

Files

show Files

Locators

show
hide
Locator:
https://www.ncbi.nlm.nih.gov/pubmed/26691751 (Any fulltext)
Description:
-
OA-Status:
Not specified

Creators

show
hide
 Creators:
Greer, E. L., Author
Becker, B.1, Author           
Latza, C.1, Author           
Antebi, A.1, Author           
Shi, Y., Author
Affiliations:
1Department Antebi - Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_1942285              

Content

show
hide
Free keywords: Animals Caenorhabditis elegans/*genetics Caenorhabditis elegans Proteins/*genetics Cholestenes/metabolism Chromatin/genetics Histone Demethylases/*genetics Histones/genetics Longevity/*genetics Methylation Mutation/*genetics Signal Transduction/genetics
 Abstract: Complex organismal properties such as longevity can be transmitted across generations by non-genetic factors. Here we demonstrate that deletion of the C. elegans histone H3 lysine 4 dimethyl (H3K4me2) demethylase, spr-5, causes a trans-generational increase in lifespan. We identify a chromatin-modifying network, which regulates this lifespan extension. We further show that this trans-generational lifespan extension is dependent on a hormonal signaling pathway involving the steroid dafachronic acid, an activator of the nuclear receptor DAF-12. These findings suggest that loss of the demethylase SPR-5 causes H3K4me2 mis-regulation and activation of a known lifespan-regulating signaling pathway, leading to trans-generational lifespan extension.

Details

show
hide
Language(s):
 Dates: 2016-022015-12-23
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: 26691751
DOI: 10.1038/cr.2015.148
ISSN: 1001-0602
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cell Res
  Alternative Title : Cell research
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 26 (2) Sequence Number: - Start / End Page: 229 - 38 Identifier: -