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  CRIS-a novel cAMP-binding protein controlling spermiogenesis and the development of flagellar bending

Krahling, A. M., Alvarez, L., Debowski, K., Van, Q., Gunkel, M., Irsen, S., et al. (2013). CRIS-a novel cAMP-binding protein controlling spermiogenesis and the development of flagellar bending. PLoS Genet, 9(12), e1003960. doi:10.1371/journal.pgen.1003960.

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Krahling, A. M., Author
Alvarez, L., Author
Debowski, K., Author
Van, Q., Author
Gunkel, M., Author
Irsen, S., Author
Al-Amoudi, A., Author
Strunker, T., Author
Kremmer, E., Author
Krause, E., Author
Voigt, I.1, Author           
Wortge, S., Author
Waisman, A., Author
Weyand, I., Author
Seifert, R., Author
Kaupp, U. B., Author
Wachten, D., Author
Affiliations:
1Transgenesis, Core Facilities, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_3394020              

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Free keywords: Animals Calcium/metabolism Carrier Proteins/*genetics Cyclic AMP/*genetics/metabolism Cyclic GMP/metabolism Flagella/*genetics/metabolism Humans Male Mice Phosphorylation Protein Binding/*genetics Signal Transduction/genetics Sperm Motility/genetics Spermatogenesis/*genetics Spermatozoa/metabolism
 Abstract: The second messengers cAMP and cGMP activate their target proteins by binding to a conserved cyclic nucleotide-binding domain (CNBD). Here, we identify and characterize an entirely novel CNBD-containing protein called CRIS (cyclic nucleotide receptor involved in sperm function) that is unrelated to any of the other members of this protein family. CRIS is exclusively expressed in sperm precursor cells. Cris-deficient male mice are either infertile due to a lack of sperm resulting from spermatogenic arrest, or subfertile due to impaired sperm motility. The motility defect is caused by altered Ca(2+) regulation of flagellar beat asymmetry, leading to a beating pattern that is reminiscent of sperm hyperactivation. Our results suggest that CRIS interacts during spermiogenesis with Ca(2+)-regulated proteins that--in mature sperm--are involved in flagellar bending.

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 Dates: 2013
 Publication Status: Issued
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 Identifiers: DOI: 10.1371/journal.pgen.1003960
ISSN: 1553-7404 (Electronic) 1553-7390 (Linking)
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Title: PLoS Genet
Source Genre: Journal
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Pages: - Volume / Issue: 9 (12) Sequence Number: - Start / End Page: e1003960 Identifier: -