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  A single mouse gene encodes the mitochondrial transcription factor A and a testis-specific nuclear HMG-box protein

Larsson, N., Garman, J. D., Oldfors, A., Barsh, G. S., & Clayton, D. A. (1996). A single mouse gene encodes the mitochondrial transcription factor A and a testis-specific nuclear HMG-box protein. Nat Genet, 13(3), 296-302. doi:10.1038/ng0796-296.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-6FED-F Version Permalink: https://hdl.handle.net/21.11116/0000-000B-6FEE-E
Genre: Journal Article

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Larsson, N.G.1, Author           
Garman, J. D., Author
Oldfors, A., Author
Barsh, G. S., Author
Clayton, D. A., Author
Affiliations:
1Department Larsson - Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_1942286              

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Free keywords: Amino Acid Sequence Animals Base Sequence Cell Nucleus/chemistry/genetics Cloning, Molecular DNA-Binding Proteins/biosynthesis/chemistry/*genetics High Mobility Group Proteins/*genetics Male Mice Mice, Inbred Strains Mitochondria/chemistry *Mitochondrial Proteins Molecular Sequence Data *Nuclear Proteins Sequence Analysis, DNA Sequence Homology, Amino Acid Spermatocytes/chemistry Testis/*chemistry/metabolism Transcription Factors/biosynthesis/chemistry/*genetics Transcription, Genetic
 Abstract: Mitochondrial transcription factor A (mtTFA) is a key regulator of mammalian mitochondrial DNA transcription. We report here that a testis-specific isoform of mouse mtTFA lacks the mitochondrial targeting sequence and is present in the nucleus of spermatocytes and elongating spermatids, thus representing the first reported mammalian gene encoding protein isoforms targeted for the mitochondria or the nucleus. The presence of the mitochondrial transcriptional activator in the nucleus raises the possibility of a role for this protein in both genetic systems. Mutations in the nuclear mtTFA gene may therefore exhibit phenotypic consequences due to altered function in either or both genetic compartments.

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 Dates: 1996-071996-07-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: 8673128
DOI: 10.1038/ng0796-296
ISSN: 1061-4036 (Print)1061-4036
 Degree: -

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Title: Nat Genet
  Alternative Title : Nature genetics
Source Genre: Journal
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Pages: - Volume / Issue: 13 (3) Sequence Number: - Start / End Page: 296 - 302 Identifier: -