非表示:
キーワード:
Amino Acid Sequence
Animals
Basic-Leucine Zipper Transcription Factors/chemistry/genetics
Conserved Sequence
DNA-Binding Proteins/chemistry/genetics
Humans
Mammals
Mitochondrial Proteins
Molecular Sequence Data
*Phylogeny
Plants/*genetics
Sequence Alignment
要旨:
The human mitochondrial transcription termination factor (mTERF) is involved in the regulation of transcription of the mitochondrial genome. Similarity searches and phylogenetic analysis demonstrate that mTERF is a member of large and complex protein family (the MTERF family) shared amongst metazoans and plants. Interestingly, we identify three novel MTERF genes in vertebrates, which all encode proteins with predicted mitochondrial localization. Members of the MTERF family have so far not been detected in fungi, supporting the notion that mitochondrial transcription regulation may have evolved separately in yeast and animal cells.