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Free keywords:
Animals
Chromatin/genetics/metabolism
*DNA Breaks, Double-Stranded
*DNA End-Joining Repair
DNA Repair
Histones/metabolism
Humans
Intracellular Signaling Peptides and Proteins/*physiology
Protein Transport
Signal Transduction
Tumor Suppressor p53-Binding Protein 1
Abstract:
DNA double-strand break (DSB) signalling and repair is crucial to preserve genomic integrity and maintain cellular homeostasis. p53-binding protein 1 (53BP1) is an important regulator of the cellular response to DSBs that promotes the end-joining of distal DNA ends, which is induced during V(D)J and class switch recombination as well as during the fusion of deprotected telomeres. New insights have been gained into the mechanisms underlying the recruitment of 53BP1 to damaged chromatin and how 53BP1 promotes non-homologous end-joining-mediated DSB repair while preventing homologous recombination. From these studies, a model is emerging in which 53BP1 recruitment requires the direct recognition of a DSB-specific histone code and its influence on pathway choice is mediated by mutual antagonism with breast cancer 1 (BRCA1).
