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  Association of host mitochondria with the parasitophorous vacuole during Toxoplasma infection is not dependent on rhoptry proteins ROP2/8

Pernas, L., & Boothroyd, J. C. (2010). Association of host mitochondria with the parasitophorous vacuole during Toxoplasma infection is not dependent on rhoptry proteins ROP2/8. Int J Parasitol, 40(12), 1367-71. doi:10.1016/j.ijpara.2010.07.002.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-7452-6 Version Permalink: https://hdl.handle.net/21.11116/0000-000B-7453-5
Genre: Journal Article

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https://www.ncbi.nlm.nih.gov/pubmed/20637758 (Any fulltext)
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 Creators:
Pernas, L.1, Author           
Boothroyd, J. C., Author
Affiliations:
1Pernas – Metabolism of Infection, Max Planck Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_3394005              

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Free keywords: Cell Line Humans Membrane Proteins/genetics/*metabolism Mitochondria/*metabolism Protozoan Proteins/genetics/*metabolism Toxoplasma/genetics/*metabolism Toxoplasmosis/*metabolism/parasitology Vacuoles/genetics/*metabolism
 Abstract: Previous work has proposed rhoptry protein 2 (ROP2) as the physical link that tethers host mitochondria to the parasitophorous vacuole membrane (PVM) surrounding the intracellular parasite, Toxoplasma gondii. A recent analysis of the ROP2 structure, however, raised questions about this model. To determine whether ROP2 is necessary, we created a parasite line that lacks the entire ROP2 locus consisting of the three closely related genes, ROP2a, ROP2b and ROP8. We show that this knockout mutant retains the ability to recruit host mitochondria in a manner that is indistinguishable from the parental strain, re-opening the question of which molecules mediate this association.

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 Dates: 2010-102010
 Publication Status: Issued
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 Rev. Type: -
 Identifiers: Other: 20637758
DOI: 10.1016/j.ijpara.2010.07.002
ISSN: 1879-0135 (Electronic)0020-7519 (Linking)
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Title: Int J Parasitol
Source Genre: Journal
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Pages: - Volume / Issue: 40 (12) Sequence Number: - Start / End Page: 1367 - 71 Identifier: -