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  A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention

Sampietro, M. L., Trompet, S., Verschuren, J. J., Talens, R. P., Deelen, J., Heijmans, B. T., de Winter, R. J., Tio, R. A., Doevendans, P. A., Ganesh, S. K., Nabel, E. G., Westra, H. J., Franke, L., van den Akker, E. B., Westendorp, R. G., Zwinderman, A. H., Kastrati, A., Koch, W., Slagboom, P. E., de Knijff, P., & Jukema, J. W. (2011). A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention. Hum Mol Genet, 20(23), 4748-57. doi:10.1093/hmg/ddr389.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-000B-7238-6 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000C-089F-9
資料種別: 学術論文

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URL:
https://www.ncbi.nlm.nih.gov/pubmed/21878436 (全文テキスト（全般）)
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Not specified

作成者

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 作成者:
Sampietro, M. L., 著者
Trompet, S., 著者
Verschuren, J. J., 著者
Talens, R. P., 著者
Deelen, J.1, 著者           
Heijmans, B. T., 著者
de Winter, R. J., 著者
Tio, R. A., 著者
Doevendans, P. A., 著者
Ganesh, S. K., 著者
Nabel, E. G., 著者
Westra, H. J., 著者
Franke, L., 著者
van den Akker, E. B., 著者
Westendorp, R. G., 著者
Zwinderman, A. H., 著者
Kastrati, A., 著者
Koch, W., 著者
Slagboom, P. E., 著者           
de Knijff, P., 著者
Jukema, J. W., 著者 全て表示
所属:
1Deelen – Genetics and Biomarkers of Human Ageing, Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_3394006              

内容説明

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キーワード: Aged *Angioplasty, Balloon, Coronary Chromosomes, Human, Pair 12/*genetics Coronary Restenosis/*genetics/mortality/*therapy Female Genetic Loci/*genetics *Genetic Predisposition to Disease *Genome-Wide Association Study Humans Male Middle Aged Polymorphism, Single Nucleotide/genetics
 要旨: Percutaneous coronary intervention (PCI) has become an effective therapy to treat obstructive coronary artery diseases (CAD). However, one of the major drawbacks of PCI is the occurrence of restenosis in 5-25% of all initially treated patients. Restenosis is defined as the re-narrowing of the lumen of the blood vessel, resulting in renewed symptoms and the need for repeated intervention. To identify genetic variants that are associated with restenosis, a genome-wide association study (GWAS) was conducted in 295 patients who developed restenosis (cases) and 571 who did not (controls) from the GENetic Determinants of Restenosis (GENDER) study. Analysis of ~550 000 single nucleotide polymorphisms (SNPs) in GENDER was followed by a replication phase in three independent case-control populations (533 cases and 3067 controls). A potential susceptibility locus for restenosis at chromosome 12, including rs10861032 (P(combined) = 1.11 x 10(-7)) and rs9804922 (P(combined) = 1.45 x 10(-6)), was identified in the GWAS and replication phase. In addition, both SNPs were also associated with coronary events (rs10861032, P(additive) = 0.005; rs9804922, P(additive) = 0.023) in a trial based cohort set of elderly patients with (enhanced risk of) CAD (PROSPER) and all-cause mortality in PROSPER (rs10861032, P(additive) = 0.007; rs9804922, P(additive) = 0.013) and GENDER (rs10861032, P(additive) = 0.005; rs9804922, P(additive) = 0.023). Further analysis suggests that this locus could be involved in regulatory functions.

資料詳細

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 日付: 2011-12-012011-09-01
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子（DOI, ISBNなど）: その他: 21878436
DOI: 10.1093/hmg/ddr389
ISSN: 1460-2083 (Electronic)0964-6906 (Linking)
 学位: -

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出版物 1

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出版物名: Hum Mol Genet
種別: 学術雑誌
 著者・編者:
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出版社, 出版地: -
ページ: - 巻号: 20 (23) 通巻号: - 開始・終了ページ: 4748 - 57 識別子（ISBN, ISSN, DOIなど）: -