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  A steroid receptor-microRNA switch regulates life span in response to signals from the gonad

Shen, Y., Wollam, J., Magner, D., Karalay, O., & Antebi, A. (2012). A steroid receptor-microRNA switch regulates life span in response to signals from the gonad. Science, 338(6113), 1472-6. doi:10.1126/science.1228967.

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Genre: Zeitschriftenartikel

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https://www.ncbi.nlm.nih.gov/pubmed/23239738 (beliebiger Volltext)
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 Urheber:
Shen, Y.1, Autor           
Wollam, J.1, Autor           
Magner, D.B.1, Autor           
Karalay, O.1, Autor           
Antebi, A.1, Autor           
Affiliations:
1Department Antebi - Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_1942285              

Inhalt

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Schlagwörter: Animals Caenorhabditis elegans/genetics/growth & development/*physiology Caenorhabditis elegans Proteins/genetics/*physiology Forkhead Transcription Factors Gene Expression Regulation, Developmental Germ Cells/metabolism Gonads/*metabolism Larva/genetics/growth & development/physiology Longevity/genetics/*physiology MicroRNAs/genetics/*metabolism Nuclear Proteins/genetics/physiology Proto-Oncogene Proteins c-akt/genetics/physiology Receptors, Cytoplasmic and Nuclear/genetics/*physiology Receptors, Steroid/genetics/*physiology Signal Transduction Transcription Factors/genetics/physiology
 Zusammenfassung: Although the gonad primarily functions in procreation, it also affects animal life span. Here, we show that removal of the Caenorhabditis elegans germ line triggers a switch in the regulatory state of the organism to promote longevity, co-opting components involved in larval developmental timing circuits. These components include the DAF-12 steroid receptor, which is involved in the larval stage two-to-stage three (L2-L3) transition and up-regulates members of the let-7 microRNA (miRNA) family. The miRNAs target an early larval nuclear factor lin-14 and akt-1/kinase, thereby stimulating DAF-16/FOXO signaling to extend life. Our studies suggest that metazoan life span is coupled to the gonad through elements of a developmental timer.

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 Datum: 2012-12-142012-12-15
 Publikationsstatus: Erschienen
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 Identifikatoren: Anderer: 23239738
DOI: 10.1126/science.1228967
ISSN: 0036-8075
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Titel: Science
  Alternativer Titel : Science (New York, N.Y.)
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 338 (6113) Artikelnummer: - Start- / Endseite: 1472 - 6 Identifikator: -