ausblenden:
Schlagwörter:
Animals
DNA Copy Number Variations
DNA, Mitochondrial/*genetics
*Evolution, Molecular
Female
Genome, Mitochondrial
Humans
Mitochondrial Diseases/*genetics
*Selection, Genetic
Zusammenfassung:
Mutations of mitochondrial DNA (mtDNA) are frequent in humans and are implicated in many different types of pathology. The high substitution rate and the maternal, asexual mode of transmission of mtDNA make it more likely to accumulate deleterious mutations. Here, we discuss recent evidence that mtDNA transmission is subject to strong purifying selection in the mammalian female germ line, limiting the accumulation of such mutations. This process shapes mitochondrial sequence diversity and is therefore probably of fundamental importance for animal evolution and in human mitochondrial disease.
