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  The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!

Wickström, S. A., Lange, A., Montanez, E., & Fassler, R. (2010). The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase! EMBO J, 29(2), 281-91. doi:10.1038/emboj.2009.376.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-000B-691D-0 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000B-691E-F
資料種別: 学術論文

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https://www.ncbi.nlm.nih.gov/pubmed/20033063 (全文テキスト(全般))
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Not specified

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 作成者:
Wickström, S. A.1, 著者           
Lange, A., 著者
Montanez, E., 著者
Fassler, R., 著者
所属:
1Wickström – Skin Homeostasis and Ageing, Max Planck Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_1942298              

内容説明

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キーワード: Amino Acid Sequence Animals DNA-Binding Proteins/genetics/*metabolism Humans Microfilament Proteins/genetics/*metabolism Molecular Sequence Data Morphogenesis Protein-Serine-Threonine Kinases/genetics/*metabolism Sequence Alignment
 要旨: Dynamic interactions of cells with their environment regulate multiple aspects of tissue morphogenesis and function. Integrins are the major class of cell surface receptors that recognize and bind extracellular matrix proteins, resulting in the engagement and organization of the cytoskeleton as well as activation of signalling pathways to regulate cell behaviour and morphogenetic processes. The ternary complex of integrin-linked kinase (ILK), PINCH, and parvin (IPP complex), which was identified more than a decade ago, interacts with the cytoplasmic tail of beta integrins and couples them to the actin cytoskeleton. In addition, ILK has been shown to act as a serine/threonine kinase and to directly activate several signalling pathways downstream of integrins. However, the kinase activity of ILK and the precise functions of the IPP complex have remained elusive and controversial. This review focuses on the recent advances made towards understanding the specialized roles this complex and its individual components have acquired during evolution.

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 日付: 2010-01-202010
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子(DOI, ISBNなど): その他: 20033063
DOI: 10.1038/emboj.2009.376
ISSN: 1460-2075 (Electronic)0261-4189 (Linking)
 学位: -

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出版物 1

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出版物名: EMBO J
種別: 学術雑誌
 著者・編者:
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出版社, 出版地: -
ページ: - 巻号: 29 (2) 通巻号: - 開始・終了ページ: 281 - 91 識別子(ISBN, ISSN, DOIなど): -