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Free keywords:
Actins/*metabolism
Animals
Cell Differentiation/*physiology
Cell Movement/*physiology
Cell Proliferation
Cell Shape/*physiology
Extracellular Matrix Proteins/*metabolism
Hemidesmosomes/chemistry/*metabolism
Humans
Mice
Muscular Dystrophies/*metabolism
Signal Transduction/*genetics
Abstract:
The development of multicellular organisms, as well as maintenance of organ architecture and function, requires robust regulation of cell fates. This is in part achieved by conserved signaling pathways through which cells process extracellular information and translate this information into changes in proliferation, differentiation, migration, and cell shape. Gene deletion studies in higher eukaryotes have assigned critical roles for components of the extracellular matrix (ECM) and their cellular receptors in a vast number of developmental processes, indicating that a large proportion of this signaling is regulated by cell-ECM interactions. In addition, genetic alterations in components of this signaling axis play causative roles in several human diseases. This review will discuss what genetic analyses in mice and lower organisms have taught us about adhesion signaling in development and disease.
