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  Ten-eleven translocation (Tet) and thymine DNA glycosylase (TDG), components of the demethylation pathway, are direct targets of miRNA-29a

Zhang, P., Huang, B., Xu, X., & Sessa, W. C. (2013). Ten-eleven translocation (Tet) and thymine DNA glycosylase (TDG), components of the demethylation pathway, are direct targets of miRNA-29a. Biochem Biophys Res Commun, 437(3), 368-73. doi:10.1016/j.bbrc.2013.06.082.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000B-68D1-4 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000B-68D2-3
Genre: Zeitschriftenartikel

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externe Referenz:
https://www.ncbi.nlm.nih.gov/pubmed/23820384 (beliebiger Volltext)
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Keine Angabe

Urheber

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 Urheber:
Zhang, P., Autor
Huang, B., Autor
Xu, X.1, Autor           
Sessa, W. C., Autor
Affiliations:
1Xu – Epigenetic Regulation of Mammalian Ageing, Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_3394009              

Inhalt

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Schlagwörter: 3' Untranslated Regions/genetics Animals Cells, Cultured DNA Methylation/*genetics DNA-Binding Proteins/antagonists & inhibitors/genetics/*metabolism Dioxygenases/antagonists & inhibitors/genetics/*metabolism Epigenetic Repression/genetics Gene Targeting/*methods HEK293 Cells Humans Mice MicroRNAs/antagonists & inhibitors/*physiology Molecular Mimicry/physiology Oxidation-Reduction Protein Binding/genetics Proto-Oncogene Proteins/antagonists & inhibitors/genetics/*metabolism RNA, Messenger/antagonists & inhibitors/biosynthesis/genetics Signal Transduction/*genetics Thymine DNA Glycosylase/antagonists & inhibitors/*biosynthesis/genetics 5hmC Epigenetics MicroRNA Tdg Tet
 Zusammenfassung: The ten-eleven translocation family of proteins (Tet1/2/3, Tets) converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), which can be further oxidized and repaired by thymine DNA glycosylase (TDG), to influence gene transcription in embryonic and adult tissues. However the mechanisms of how Tets and TDG levels are regulated are unknown. We show that miR-29 can directly regulate Tet1-3 and TDG mRNA levels through binding to their 3'UTRs. miR-29 mimic decreases global 5hmC levels, a hallmark of Tet activity. Moreover, the mRNA levels for Tet3 and TDG are inversely correlated with the levels of miR-29 in aged mouse aorta implying that aging may affect methylation patterns via miRNA. In summary, our data show that Tets and TDG are direct targets of miR-29 and unravel a novel regulatory role for this miRNA in epigenetic DNA demethylation pathways.

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 Datum: 2013-08-022013
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: Anderer: 23820384
DOI: 10.1016/j.bbrc.2013.06.082
ISSN: 1090-2104 (Electronic)0006-291X (Linking)
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Titel: Biochem Biophys Res Commun
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 437 (3) Artikelnummer: - Start- / Endseite: 368 - 73 Identifikator: -