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  Robust cell identity specifications through transitions in the collective state of growing developmental systems

Stanoev, A., & Koseska, A. (2022). Robust cell identity specifications through transitions in the collective state of growing developmental systems. Current Opinion in Systems Biology, 100437. doi:10.1016/j.coisb.2022.100437.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-6DE8-6 Version Permalink: https://hdl.handle.net/21.11116/0000-000F-34B9-6
Genre: Journal Article

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1-s2.0-S2452310022000233-main.pdf (Publisher version), 2MB
 
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https://www.sciencedirect.com/science/article/abs/pii/S2452310022000233 (Publisher version)
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 Creators:
Stanoev, Angel1, Author
Koseska, Aneta2, Author                 
Affiliations:
1External Organizations, ou_persistent22              
2Lise Meitner Group Cellular Computations and Learning, Max Planck Institute for Neurobiology of Behavior – caesar, Max Planck Society, ou_3361763              

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 Abstract: Mammalian development is characterized with transitions from homogeneous populations of precursor to heterogeneous population of specified cells. We review here the main dynamical mechanisms through which such transitions are conceptualized, and discuss that the differentiation timing, robust cell-type proportions and recovery upon perturbation are emergent property of proliferating and communicating cell populations. We argue that studying developmental systems using transitions in collective system states is necessary to describe observed experimental features, and propose additionally the basis of a novel analytical method to deduce the relationship between single-cell dynamics and the collective, symmetry-broken states in cellular populations.

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Language(s): eng - English
 Dates: 2022-11-08
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.coisb.2022.100437
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Title: Current Opinion in Systems Biology
  Abbreviation : Curr Opin Syst Biol
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: - Sequence Number: 100437 Start / End Page: - Identifier: Other: 2452-3100
CoNE: https://pure.mpg.de/cone/journals/resource/2452-3100