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Abstract:
The MPI Bioinformatics Toolkit (https://toolkit.tuebingen.mpg.de [1,2]) provides interactive access to a wide array of the best-performing bioinformatics tools and databases, including the state-of-the-
art protein sequence comparison methods HHblits and HHpred. In this talk, I will discuss the application of the Toolkit for detecting remote homologs, inferring protein function, and visualizing relationships in large sequence datasets. I will demonstrate these using, as an example, the coiled-coil segment-containing OmpM protein superfamily, whose members tether the outer membrane to the peptidoglycan layer in many Gram-negative bacteria [3].
